Controlled masking and targeted release of redox-cycling ortho-quinones via a C–C bond-cleaving 1,6-elimination

Natural products that contain ortho-quinones show great potential as anticancer agents but have been largely discarded from clinical development because their redox-cycling behaviour results in general systemic toxicity. Here we report conjugation of ortho-quinones to a carrier, which simultaneously...

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Detalles Bibliográficos
Autores principales: Dunsmore, Lavinia, Navo, Claudio D., Becher, Julie, de Montes, Enrique Gil, Guerreiro, Ana, Hoyt, Emily, Brown, Libby, Zelenay, Viviane, Mikutis, Sigitas, Cooper, Jonathan, Barbieri, Isaia, Lawrinowitz, Stefanie, Siouve, Elise, Martin, Esther, Ruivo, Pedro R., Rodrigues, Tiago, da Cruz, Filipa P., Werz, Oliver, Vassiliou, George, Ravn, Peter, Jiménez-Osés, Gonzalo, Bernardes, Gonçalo J. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252919/
https://www.ncbi.nlm.nih.gov/pubmed/35764792
http://dx.doi.org/10.1038/s41557-022-00964-7

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