Myotonic dystrophy RNA toxicity alters morphology, adhesion and migration of mouse and human astrocytes

Brain dysfunction in myotonic dystrophy type 1 (DM1), the prototype of toxic RNA disorders, has been mainly attributed to neuronal RNA misprocessing, while little attention has been given to non-neuronal brain cells. Here, using a transgenic mouse model of DM1 that expresses mutant RNA in various br...

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Detalles Bibliográficos
Autores principales: Dincã, Diana M., Lallemant, Louison, González-Barriga, Anchel, Cresto, Noémie, Braz, Sandra O., Sicot, Géraldine, Pillet, Laure-Elise, Polvèche, Hélène, Magneron, Paul, Huguet-Lachon, Aline, Benyamine, Hélène, Azotla-Vilchis, Cuauhtli N., Agonizantes-Juárez, Luis E., Tahraoui-Bories, Julie, Martinat, Cécile, Hernández-Hernández, Oscar, Auboeuf, Didier, Rouach, Nathalie, Bourgeois, Cyril F., Gourdon, Geneviève, Gomes-Pereira, Mário
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253038/
https://www.ncbi.nlm.nih.gov/pubmed/35789154
http://dx.doi.org/10.1038/s41467-022-31594-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253038/
https://www.ncbi.nlm.nih.gov/pubmed/35789154
http://dx.doi.org/10.1038/s41467-022-31594-9

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