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Vaginal Microbiota Changes Caused by HPV Infection in Chinese Women

Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases. After studying 602 unvaccinated Chinese women using 16S rRNA to detect cervical-vaginal microecology, we analyzed the relationship between HPV infection and vaginal microecology including 20 HPV types. In C...

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Autores principales: Zhang, Yichan, Xu, Xiaolin, Yu, Liqun, Shi, Xingxian, Min, Min, Xiong, Lijuan, Pan, Jia, Zhang, Yong, Liu, Peipei, Wu, Guizhen, Gao, Guolan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253274/
https://www.ncbi.nlm.nih.gov/pubmed/35800384
http://dx.doi.org/10.3389/fcimb.2022.814668
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author Zhang, Yichan
Xu, Xiaolin
Yu, Liqun
Shi, Xingxian
Min, Min
Xiong, Lijuan
Pan, Jia
Zhang, Yong
Liu, Peipei
Wu, Guizhen
Gao, Guolan
author_facet Zhang, Yichan
Xu, Xiaolin
Yu, Liqun
Shi, Xingxian
Min, Min
Xiong, Lijuan
Pan, Jia
Zhang, Yong
Liu, Peipei
Wu, Guizhen
Gao, Guolan
author_sort Zhang, Yichan
collection PubMed
description Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases. After studying 602 unvaccinated Chinese women using 16S rRNA to detect cervical-vaginal microecology, we analyzed the relationship between HPV infection and vaginal microecology including 20 HPV types. In Chinese women, L. gasseri–dominated and L. jensenii–dominated clusters were significantly absence. Microbial alpha diversity was significantly higher in HPV-infected and cervical intraepithelial neoplasia (CIN)–diagnosed groups than in healthy control group. Certain bacteria were associated with HPV infection and CIN, including Streptococcus, Prevotella, Chlamydia, Bifidobacterium, Ralstonia, and Aerococcus. With the development of disease, the proportions of community state type III (CST-III) and CST-IV-B gradually increased, whereas the proportions of CST-I and CST-IV-A gradually decreased. In addition, age was an influential factor for HPV infection. With aging, the probability of HPV infection and the proportion of CST-IV-B increase. In conclusion, our study was a large cross-sectional study that evaluated the relationship between vaginal microbiota and HPV infection, and brought essential comparable data.
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spelling pubmed-92532742022-07-06 Vaginal Microbiota Changes Caused by HPV Infection in Chinese Women Zhang, Yichan Xu, Xiaolin Yu, Liqun Shi, Xingxian Min, Min Xiong, Lijuan Pan, Jia Zhang, Yong Liu, Peipei Wu, Guizhen Gao, Guolan Front Cell Infect Microbiol Cellular and Infection Microbiology Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases. After studying 602 unvaccinated Chinese women using 16S rRNA to detect cervical-vaginal microecology, we analyzed the relationship between HPV infection and vaginal microecology including 20 HPV types. In Chinese women, L. gasseri–dominated and L. jensenii–dominated clusters were significantly absence. Microbial alpha diversity was significantly higher in HPV-infected and cervical intraepithelial neoplasia (CIN)–diagnosed groups than in healthy control group. Certain bacteria were associated with HPV infection and CIN, including Streptococcus, Prevotella, Chlamydia, Bifidobacterium, Ralstonia, and Aerococcus. With the development of disease, the proportions of community state type III (CST-III) and CST-IV-B gradually increased, whereas the proportions of CST-I and CST-IV-A gradually decreased. In addition, age was an influential factor for HPV infection. With aging, the probability of HPV infection and the proportion of CST-IV-B increase. In conclusion, our study was a large cross-sectional study that evaluated the relationship between vaginal microbiota and HPV infection, and brought essential comparable data. Frontiers Media S.A. 2022-06-21 /pmc/articles/PMC9253274/ /pubmed/35800384 http://dx.doi.org/10.3389/fcimb.2022.814668 Text en Copyright © 2022 Zhang, Xu, Yu, Shi, Min, Xiong, Pan, Zhang, Liu, Wu and Gao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Zhang, Yichan
Xu, Xiaolin
Yu, Liqun
Shi, Xingxian
Min, Min
Xiong, Lijuan
Pan, Jia
Zhang, Yong
Liu, Peipei
Wu, Guizhen
Gao, Guolan
Vaginal Microbiota Changes Caused by HPV Infection in Chinese Women
title Vaginal Microbiota Changes Caused by HPV Infection in Chinese Women
title_full Vaginal Microbiota Changes Caused by HPV Infection in Chinese Women
title_fullStr Vaginal Microbiota Changes Caused by HPV Infection in Chinese Women
title_full_unstemmed Vaginal Microbiota Changes Caused by HPV Infection in Chinese Women
title_short Vaginal Microbiota Changes Caused by HPV Infection in Chinese Women
title_sort vaginal microbiota changes caused by hpv infection in chinese women
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253274/
https://www.ncbi.nlm.nih.gov/pubmed/35800384
http://dx.doi.org/10.3389/fcimb.2022.814668
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