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Vaginal Microbiota Changes Caused by HPV Infection in Chinese Women
Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases. After studying 602 unvaccinated Chinese women using 16S rRNA to detect cervical-vaginal microecology, we analyzed the relationship between HPV infection and vaginal microecology including 20 HPV types. In C...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253274/ https://www.ncbi.nlm.nih.gov/pubmed/35800384 http://dx.doi.org/10.3389/fcimb.2022.814668 |
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author | Zhang, Yichan Xu, Xiaolin Yu, Liqun Shi, Xingxian Min, Min Xiong, Lijuan Pan, Jia Zhang, Yong Liu, Peipei Wu, Guizhen Gao, Guolan |
author_facet | Zhang, Yichan Xu, Xiaolin Yu, Liqun Shi, Xingxian Min, Min Xiong, Lijuan Pan, Jia Zhang, Yong Liu, Peipei Wu, Guizhen Gao, Guolan |
author_sort | Zhang, Yichan |
collection | PubMed |
description | Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases. After studying 602 unvaccinated Chinese women using 16S rRNA to detect cervical-vaginal microecology, we analyzed the relationship between HPV infection and vaginal microecology including 20 HPV types. In Chinese women, L. gasseri–dominated and L. jensenii–dominated clusters were significantly absence. Microbial alpha diversity was significantly higher in HPV-infected and cervical intraepithelial neoplasia (CIN)–diagnosed groups than in healthy control group. Certain bacteria were associated with HPV infection and CIN, including Streptococcus, Prevotella, Chlamydia, Bifidobacterium, Ralstonia, and Aerococcus. With the development of disease, the proportions of community state type III (CST-III) and CST-IV-B gradually increased, whereas the proportions of CST-I and CST-IV-A gradually decreased. In addition, age was an influential factor for HPV infection. With aging, the probability of HPV infection and the proportion of CST-IV-B increase. In conclusion, our study was a large cross-sectional study that evaluated the relationship between vaginal microbiota and HPV infection, and brought essential comparable data. |
format | Online Article Text |
id | pubmed-9253274 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92532742022-07-06 Vaginal Microbiota Changes Caused by HPV Infection in Chinese Women Zhang, Yichan Xu, Xiaolin Yu, Liqun Shi, Xingxian Min, Min Xiong, Lijuan Pan, Jia Zhang, Yong Liu, Peipei Wu, Guizhen Gao, Guolan Front Cell Infect Microbiol Cellular and Infection Microbiology Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases. After studying 602 unvaccinated Chinese women using 16S rRNA to detect cervical-vaginal microecology, we analyzed the relationship between HPV infection and vaginal microecology including 20 HPV types. In Chinese women, L. gasseri–dominated and L. jensenii–dominated clusters were significantly absence. Microbial alpha diversity was significantly higher in HPV-infected and cervical intraepithelial neoplasia (CIN)–diagnosed groups than in healthy control group. Certain bacteria were associated with HPV infection and CIN, including Streptococcus, Prevotella, Chlamydia, Bifidobacterium, Ralstonia, and Aerococcus. With the development of disease, the proportions of community state type III (CST-III) and CST-IV-B gradually increased, whereas the proportions of CST-I and CST-IV-A gradually decreased. In addition, age was an influential factor for HPV infection. With aging, the probability of HPV infection and the proportion of CST-IV-B increase. In conclusion, our study was a large cross-sectional study that evaluated the relationship between vaginal microbiota and HPV infection, and brought essential comparable data. Frontiers Media S.A. 2022-06-21 /pmc/articles/PMC9253274/ /pubmed/35800384 http://dx.doi.org/10.3389/fcimb.2022.814668 Text en Copyright © 2022 Zhang, Xu, Yu, Shi, Min, Xiong, Pan, Zhang, Liu, Wu and Gao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Zhang, Yichan Xu, Xiaolin Yu, Liqun Shi, Xingxian Min, Min Xiong, Lijuan Pan, Jia Zhang, Yong Liu, Peipei Wu, Guizhen Gao, Guolan Vaginal Microbiota Changes Caused by HPV Infection in Chinese Women |
title | Vaginal Microbiota Changes Caused by HPV Infection in Chinese Women |
title_full | Vaginal Microbiota Changes Caused by HPV Infection in Chinese Women |
title_fullStr | Vaginal Microbiota Changes Caused by HPV Infection in Chinese Women |
title_full_unstemmed | Vaginal Microbiota Changes Caused by HPV Infection in Chinese Women |
title_short | Vaginal Microbiota Changes Caused by HPV Infection in Chinese Women |
title_sort | vaginal microbiota changes caused by hpv infection in chinese women |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253274/ https://www.ncbi.nlm.nih.gov/pubmed/35800384 http://dx.doi.org/10.3389/fcimb.2022.814668 |
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