Cellular Mechanisms Underlying B Cell Abnormalities in Patients With Gain-of-Function Mutations in the PIK3CD Gene

BACKGROUND: Activated phosphoinositide 3 kinase (PI3K) -delta syndrome (APDS) is an inborn error of immunity with variable clinical phenotype of immunodeficiency and immune dysregulation and caused by gain-of-function mutations in PIK3CD. The hallmark of immune phenotype is increased proportions of...

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Detalles Bibliográficos
Autores principales: Wang, Wenjie, Min, Qing, Lai, Nannan, Csomos, Krisztian, Wang, Ying, Liu, Luyao, Meng, Xin, Sun, Jinqiao, Hou, Jia, Ying, Wenjing, Zhou, Qinhua, Sun, Bijun, Hui, Xiaoying, Ujhazi, Boglarka, Gordon, Sumai, Buchbinder, David, Schuetz, Catharina, Butte, Manish, Walter, Jolan E., Wang, Xiaochuan, Wang, Ji-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253290/
https://www.ncbi.nlm.nih.gov/pubmed/35799777
http://dx.doi.org/10.3389/fimmu.2022.890073

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