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Mechanistic insights into accelerated α-synuclein aggregation mediated by human microbiome-associated functional amyloids

The gut microbiome has been shown to have key implications in the pathogenesis of Parkinson’s disease (PD). The Escherichia coli functional amyloid CsgA is known to accelerate α-synuclein aggregation in vitro and induce PD symptoms in mice. However, the mechanism governing CsgA-mediated acceleration...

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Detalles Bibliográficos
Autores principales:	Bhoite, Sujeet S., Han, Yilin, Ruotolo, Brandon T., Chapman, Matthew R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253359/ https://www.ncbi.nlm.nih.gov/pubmed/35654142 http://dx.doi.org/10.1016/j.jbc.2022.102088

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