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Hypovitaminosis D Is Prevalent in Patients With Renal AL Amyloidosis and Associated With Renal Outcome

INTRODUCTION: Vitamin D deficiency is common, but no data have been reported on vitamin D levels in light chain (AL) amyloidosis. PATIENTS AND METHODS: In this exploratory study, stored serum samples from 173 patients with newly diagnosed AL amyloidosis were analyzed for vitamin studies which includ...

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Autores principales: Muchtar, Eli, Drake, Matthew T., Leung, Nelson, Dispenzieri, Angela, Lacy, Martha Q., Buadi, Francis K., Dingli, David, Hayman, Suzanne R., Kapoor, Prashant, Hwa, Yi Lisa, Fonder, Amie, Hobbs, Miriam, Gonsalves, Wilson, Kourelis, Taxiarchis V., Warsame, Rahma, Russell, Stephen, Go, Ronald S., Binder, Moritz, Kyle, Robert A., Rajkumar, S. Vincent, Kumar, Shaji K., Gertz, Morie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253369/
https://www.ncbi.nlm.nih.gov/pubmed/35800433
http://dx.doi.org/10.3389/fendo.2022.891712
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author Muchtar, Eli
Drake, Matthew T.
Leung, Nelson
Dispenzieri, Angela
Lacy, Martha Q.
Buadi, Francis K.
Dingli, David
Hayman, Suzanne R.
Kapoor, Prashant
Hwa, Yi Lisa
Fonder, Amie
Hobbs, Miriam
Gonsalves, Wilson
Kourelis, Taxiarchis V.
Warsame, Rahma
Russell, Stephen
Go, Ronald S.
Binder, Moritz
Kyle, Robert A.
Rajkumar, S. Vincent
Kumar, Shaji K.
Gertz, Morie A.
author_facet Muchtar, Eli
Drake, Matthew T.
Leung, Nelson
Dispenzieri, Angela
Lacy, Martha Q.
Buadi, Francis K.
Dingli, David
Hayman, Suzanne R.
Kapoor, Prashant
Hwa, Yi Lisa
Fonder, Amie
Hobbs, Miriam
Gonsalves, Wilson
Kourelis, Taxiarchis V.
Warsame, Rahma
Russell, Stephen
Go, Ronald S.
Binder, Moritz
Kyle, Robert A.
Rajkumar, S. Vincent
Kumar, Shaji K.
Gertz, Morie A.
author_sort Muchtar, Eli
collection PubMed
description INTRODUCTION: Vitamin D deficiency is common, but no data have been reported on vitamin D levels in light chain (AL) amyloidosis. PATIENTS AND METHODS: In this exploratory study, stored serum samples from 173 patients with newly diagnosed AL amyloidosis were analyzed for vitamin studies which included 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D [1,25(OH)(2)D] and vitamin D binding protein (DBP). Measurements were made by liquid chromatography-tandem mass spectrometry. Kidney survival and overall survival (OS) were assessed in association to vitamin D status. RESULTS: Cardiac and kidney involvement occurred in 69% and 63% of patients, respectively. 25(OH)D deficiency (<20 ng/mL) was seen in 56.6% of the patients and was notably found among patients with heavy proteinuria (96%), hypoalbuminemia (84.3%) and morbidly obese patients (68.3%). Heavy proteinuria (>5 gr/24-h) and vitamin D supplementation were independent predictors of 25(OH)D level on nominal multivariate regression analysis. 1,25(0H)(2)D deficiency was noted in 37.6% of patients and was independently associated with low eGFR and hypoalbuminemia. Progression to ESRD occurred in 23.7% of evaluable patients. Patients who progressed to ESRD had lower serum 25(OH)D and 1,25(OH)(2)D levels compared to those who did not progress to ESRD. On a multivariate analysis, severe 25(OH)D deficiency was an independent predictor of progression to ESRD as was renal stage, while 1,25(OH)(2)D deficiency was not. CONCLUSIONS: Hypovitaminosis D is common in AL amyloidosis, particularly among patients with heavy proteinuria. Severe 25(OH)D deficiency at time of diagnosis predicts progression to ESRD.
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spelling pubmed-92533692022-07-06 Hypovitaminosis D Is Prevalent in Patients With Renal AL Amyloidosis and Associated With Renal Outcome Muchtar, Eli Drake, Matthew T. Leung, Nelson Dispenzieri, Angela Lacy, Martha Q. Buadi, Francis K. Dingli, David Hayman, Suzanne R. Kapoor, Prashant Hwa, Yi Lisa Fonder, Amie Hobbs, Miriam Gonsalves, Wilson Kourelis, Taxiarchis V. Warsame, Rahma Russell, Stephen Go, Ronald S. Binder, Moritz Kyle, Robert A. Rajkumar, S. Vincent Kumar, Shaji K. Gertz, Morie A. Front Endocrinol (Lausanne) Endocrinology INTRODUCTION: Vitamin D deficiency is common, but no data have been reported on vitamin D levels in light chain (AL) amyloidosis. PATIENTS AND METHODS: In this exploratory study, stored serum samples from 173 patients with newly diagnosed AL amyloidosis were analyzed for vitamin studies which included 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D [1,25(OH)(2)D] and vitamin D binding protein (DBP). Measurements were made by liquid chromatography-tandem mass spectrometry. Kidney survival and overall survival (OS) were assessed in association to vitamin D status. RESULTS: Cardiac and kidney involvement occurred in 69% and 63% of patients, respectively. 25(OH)D deficiency (<20 ng/mL) was seen in 56.6% of the patients and was notably found among patients with heavy proteinuria (96%), hypoalbuminemia (84.3%) and morbidly obese patients (68.3%). Heavy proteinuria (>5 gr/24-h) and vitamin D supplementation were independent predictors of 25(OH)D level on nominal multivariate regression analysis. 1,25(0H)(2)D deficiency was noted in 37.6% of patients and was independently associated with low eGFR and hypoalbuminemia. Progression to ESRD occurred in 23.7% of evaluable patients. Patients who progressed to ESRD had lower serum 25(OH)D and 1,25(OH)(2)D levels compared to those who did not progress to ESRD. On a multivariate analysis, severe 25(OH)D deficiency was an independent predictor of progression to ESRD as was renal stage, while 1,25(OH)(2)D deficiency was not. CONCLUSIONS: Hypovitaminosis D is common in AL amyloidosis, particularly among patients with heavy proteinuria. Severe 25(OH)D deficiency at time of diagnosis predicts progression to ESRD. Frontiers Media S.A. 2022-06-21 /pmc/articles/PMC9253369/ /pubmed/35800433 http://dx.doi.org/10.3389/fendo.2022.891712 Text en Copyright © 2022 Muchtar, Drake, Leung, Dispenzieri, Lacy, Buadi, Dingli, Hayman, Kapoor, Hwa, Fonder, Hobbs, Gonsalves, Kourelis, Warsame, Russell, Go, Binder, Kyle, Rajkumar, Kumar and Gertz https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Muchtar, Eli
Drake, Matthew T.
Leung, Nelson
Dispenzieri, Angela
Lacy, Martha Q.
Buadi, Francis K.
Dingli, David
Hayman, Suzanne R.
Kapoor, Prashant
Hwa, Yi Lisa
Fonder, Amie
Hobbs, Miriam
Gonsalves, Wilson
Kourelis, Taxiarchis V.
Warsame, Rahma
Russell, Stephen
Go, Ronald S.
Binder, Moritz
Kyle, Robert A.
Rajkumar, S. Vincent
Kumar, Shaji K.
Gertz, Morie A.
Hypovitaminosis D Is Prevalent in Patients With Renal AL Amyloidosis and Associated With Renal Outcome
title Hypovitaminosis D Is Prevalent in Patients With Renal AL Amyloidosis and Associated With Renal Outcome
title_full Hypovitaminosis D Is Prevalent in Patients With Renal AL Amyloidosis and Associated With Renal Outcome
title_fullStr Hypovitaminosis D Is Prevalent in Patients With Renal AL Amyloidosis and Associated With Renal Outcome
title_full_unstemmed Hypovitaminosis D Is Prevalent in Patients With Renal AL Amyloidosis and Associated With Renal Outcome
title_short Hypovitaminosis D Is Prevalent in Patients With Renal AL Amyloidosis and Associated With Renal Outcome
title_sort hypovitaminosis d is prevalent in patients with renal al amyloidosis and associated with renal outcome
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253369/
https://www.ncbi.nlm.nih.gov/pubmed/35800433
http://dx.doi.org/10.3389/fendo.2022.891712
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