Case Report: Successful Treatment With Monoclonal Antibodies in One APDS Patient With Prolonged SARS-CoV-2 Infection Not Responsive to Previous Lines of Treatment

We described the case of a patient affected by activated PI3K-kinase delta syndrome (APDS) and a long-lasting and pauci-symptomatic SARS-CoV-2 infection, treated with multiple therapeutic agents including remdesivir and SARS-CoV-2-neutralizing monoclonal antibodies. We detected the clearance of the...

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Autores principales: Rivalta, Beatrice, Amodio, Donato, Giancotta, Carmela, Santilli, Veronica, Pacillo, Lucia, Zangari, Paola, Cotugno, Nicola, Manno, Emma Concetta, Finocchi, Andrea, Bernardi, Stefania, Colagrossi, Luna, Gentile, Leonarda, Russo, Cristina, Perno, Carlo Federico, Rossi, Paolo, Cancrini, Caterina, Palma, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253383/
https://www.ncbi.nlm.nih.gov/pubmed/35799775
http://dx.doi.org/10.3389/fimmu.2022.891274
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author Rivalta, Beatrice
Amodio, Donato
Giancotta, Carmela
Santilli, Veronica
Pacillo, Lucia
Zangari, Paola
Cotugno, Nicola
Manno, Emma Concetta
Finocchi, Andrea
Bernardi, Stefania
Colagrossi, Luna
Gentile, Leonarda
Russo, Cristina
Perno, Carlo Federico
Rossi, Paolo
Cancrini, Caterina
Palma, Paolo
author_facet Rivalta, Beatrice
Amodio, Donato
Giancotta, Carmela
Santilli, Veronica
Pacillo, Lucia
Zangari, Paola
Cotugno, Nicola
Manno, Emma Concetta
Finocchi, Andrea
Bernardi, Stefania
Colagrossi, Luna
Gentile, Leonarda
Russo, Cristina
Perno, Carlo Federico
Rossi, Paolo
Cancrini, Caterina
Palma, Paolo
author_sort Rivalta, Beatrice
collection PubMed
description We described the case of a patient affected by activated PI3K-kinase delta syndrome (APDS) and a long-lasting and pauci-symptomatic SARS-CoV-2 infection, treated with multiple therapeutic agents including remdesivir and SARS-CoV-2-neutralizing monoclonal antibodies. We detected the clearance of the virus 105 days from the first positive swab and 7 days after monoclonal antibody administration. At genotyping, the SARS-CoV-2 virus resulted as wild type on all samples tested. This case shows the monoclonal antibodies’ good tolerability and efficacy in reducing viral shedding in long-lasting infections refractory to other treatments.
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spelling pubmed-92533832022-07-06 Case Report: Successful Treatment With Monoclonal Antibodies in One APDS Patient With Prolonged SARS-CoV-2 Infection Not Responsive to Previous Lines of Treatment Rivalta, Beatrice Amodio, Donato Giancotta, Carmela Santilli, Veronica Pacillo, Lucia Zangari, Paola Cotugno, Nicola Manno, Emma Concetta Finocchi, Andrea Bernardi, Stefania Colagrossi, Luna Gentile, Leonarda Russo, Cristina Perno, Carlo Federico Rossi, Paolo Cancrini, Caterina Palma, Paolo Front Immunol Immunology We described the case of a patient affected by activated PI3K-kinase delta syndrome (APDS) and a long-lasting and pauci-symptomatic SARS-CoV-2 infection, treated with multiple therapeutic agents including remdesivir and SARS-CoV-2-neutralizing monoclonal antibodies. We detected the clearance of the virus 105 days from the first positive swab and 7 days after monoclonal antibody administration. At genotyping, the SARS-CoV-2 virus resulted as wild type on all samples tested. This case shows the monoclonal antibodies’ good tolerability and efficacy in reducing viral shedding in long-lasting infections refractory to other treatments. Frontiers Media S.A. 2022-06-21 /pmc/articles/PMC9253383/ /pubmed/35799775 http://dx.doi.org/10.3389/fimmu.2022.891274 Text en Copyright © 2022 Rivalta, Amodio, Giancotta, Santilli, Pacillo, Zangari, Cotugno, Manno, Finocchi, Bernardi, Colagrossi, Gentile, Russo, Perno, Rossi, Cancrini and Palma https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Rivalta, Beatrice
Amodio, Donato
Giancotta, Carmela
Santilli, Veronica
Pacillo, Lucia
Zangari, Paola
Cotugno, Nicola
Manno, Emma Concetta
Finocchi, Andrea
Bernardi, Stefania
Colagrossi, Luna
Gentile, Leonarda
Russo, Cristina
Perno, Carlo Federico
Rossi, Paolo
Cancrini, Caterina
Palma, Paolo
Case Report: Successful Treatment With Monoclonal Antibodies in One APDS Patient With Prolonged SARS-CoV-2 Infection Not Responsive to Previous Lines of Treatment
title Case Report: Successful Treatment With Monoclonal Antibodies in One APDS Patient With Prolonged SARS-CoV-2 Infection Not Responsive to Previous Lines of Treatment
title_full Case Report: Successful Treatment With Monoclonal Antibodies in One APDS Patient With Prolonged SARS-CoV-2 Infection Not Responsive to Previous Lines of Treatment
title_fullStr Case Report: Successful Treatment With Monoclonal Antibodies in One APDS Patient With Prolonged SARS-CoV-2 Infection Not Responsive to Previous Lines of Treatment
title_full_unstemmed Case Report: Successful Treatment With Monoclonal Antibodies in One APDS Patient With Prolonged SARS-CoV-2 Infection Not Responsive to Previous Lines of Treatment
title_short Case Report: Successful Treatment With Monoclonal Antibodies in One APDS Patient With Prolonged SARS-CoV-2 Infection Not Responsive to Previous Lines of Treatment
title_sort case report: successful treatment with monoclonal antibodies in one apds patient with prolonged sars-cov-2 infection not responsive to previous lines of treatment
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253383/
https://www.ncbi.nlm.nih.gov/pubmed/35799775
http://dx.doi.org/10.3389/fimmu.2022.891274
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