Cargando…

A simple time-to-event model with NONMEM featuring right-censoring

In healthcare situations, time-to-event (TTE) data are common outcomes. A parametric approach is often employed to handle TTE data because it is possible to easily visualize different scenarios via simulation. Not all pharmacometricians are familiar with the use of non-linear mixed effects models (N...

Descripción completa

Detalles Bibliográficos
Autores principales: Tran, Quyen Thi, Chae, Jung-woo, Bae, Kyun-Seop, Yun, Hwi-yeol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Clinical Pharmacology and Therapeutics 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253447/
https://www.ncbi.nlm.nih.gov/pubmed/35800666
http://dx.doi.org/10.12793/tcp.2022.30.e8
Descripción
Sumario:In healthcare situations, time-to-event (TTE) data are common outcomes. A parametric approach is often employed to handle TTE data because it is possible to easily visualize different scenarios via simulation. Not all pharmacometricians are familiar with the use of non-linear mixed effects models (NONMEMs) to deal with TTE data. Therefore, this tutorial simply explains how to analyze TTE data using NONMEM. We show how to write the code and evaluate the model. We also provide an example of a hands-on model for training.