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A simple time-to-event model with NONMEM featuring right-censoring
In healthcare situations, time-to-event (TTE) data are common outcomes. A parametric approach is often employed to handle TTE data because it is possible to easily visualize different scenarios via simulation. Not all pharmacometricians are familiar with the use of non-linear mixed effects models (N...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Clinical Pharmacology and Therapeutics
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253447/ https://www.ncbi.nlm.nih.gov/pubmed/35800666 http://dx.doi.org/10.12793/tcp.2022.30.e8 |
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author | Tran, Quyen Thi Chae, Jung-woo Bae, Kyun-Seop Yun, Hwi-yeol |
author_facet | Tran, Quyen Thi Chae, Jung-woo Bae, Kyun-Seop Yun, Hwi-yeol |
author_sort | Tran, Quyen Thi |
collection | PubMed |
description | In healthcare situations, time-to-event (TTE) data are common outcomes. A parametric approach is often employed to handle TTE data because it is possible to easily visualize different scenarios via simulation. Not all pharmacometricians are familiar with the use of non-linear mixed effects models (NONMEMs) to deal with TTE data. Therefore, this tutorial simply explains how to analyze TTE data using NONMEM. We show how to write the code and evaluate the model. We also provide an example of a hands-on model for training. |
format | Online Article Text |
id | pubmed-9253447 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Korean Society for Clinical Pharmacology and Therapeutics |
record_format | MEDLINE/PubMed |
spelling | pubmed-92534472022-07-06 A simple time-to-event model with NONMEM featuring right-censoring Tran, Quyen Thi Chae, Jung-woo Bae, Kyun-Seop Yun, Hwi-yeol Transl Clin Pharmacol Tutorial In healthcare situations, time-to-event (TTE) data are common outcomes. A parametric approach is often employed to handle TTE data because it is possible to easily visualize different scenarios via simulation. Not all pharmacometricians are familiar with the use of non-linear mixed effects models (NONMEMs) to deal with TTE data. Therefore, this tutorial simply explains how to analyze TTE data using NONMEM. We show how to write the code and evaluate the model. We also provide an example of a hands-on model for training. Korean Society for Clinical Pharmacology and Therapeutics 2022-06 2022-06-15 /pmc/articles/PMC9253447/ /pubmed/35800666 http://dx.doi.org/10.12793/tcp.2022.30.e8 Text en Copyright © 2022 Translational and Clinical Pharmacology https://creativecommons.org/licenses/by-nc/4.0/It is identical to the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/). |
spellingShingle | Tutorial Tran, Quyen Thi Chae, Jung-woo Bae, Kyun-Seop Yun, Hwi-yeol A simple time-to-event model with NONMEM featuring right-censoring |
title | A simple time-to-event model with NONMEM featuring right-censoring |
title_full | A simple time-to-event model with NONMEM featuring right-censoring |
title_fullStr | A simple time-to-event model with NONMEM featuring right-censoring |
title_full_unstemmed | A simple time-to-event model with NONMEM featuring right-censoring |
title_short | A simple time-to-event model with NONMEM featuring right-censoring |
title_sort | simple time-to-event model with nonmem featuring right-censoring |
topic | Tutorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253447/ https://www.ncbi.nlm.nih.gov/pubmed/35800666 http://dx.doi.org/10.12793/tcp.2022.30.e8 |
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