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Therapeutic effect of antihypertensive drug on diabetic nephropathy: Functional and structural kidney investigation

Due to the growth of diabetic mellitus (DM) and diabetic nephropathy as a significant complication for diabetic patients, study on effective treatment with fewer side effects has been fascinated. In this study for the first time carvedilol effects on both function and structure of kidney in diabetic...

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Autores principales: Masoumeh Ghoreishi, Seyedeh, Amiri, Mehrangiz, Shabestani Monfared, Ali, Hamidi, Faezeh, Najafzadehvarzi, Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253481/
https://www.ncbi.nlm.nih.gov/pubmed/35800144
http://dx.doi.org/10.1016/j.sjbs.2022.103353
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author Masoumeh Ghoreishi, Seyedeh
Amiri, Mehrangiz
Shabestani Monfared, Ali
Hamidi, Faezeh
Najafzadehvarzi, Hossein
author_facet Masoumeh Ghoreishi, Seyedeh
Amiri, Mehrangiz
Shabestani Monfared, Ali
Hamidi, Faezeh
Najafzadehvarzi, Hossein
author_sort Masoumeh Ghoreishi, Seyedeh
collection PubMed
description Due to the growth of diabetic mellitus (DM) and diabetic nephropathy as a significant complication for diabetic patients, study on effective treatment with fewer side effects has been fascinated. In this study for the first time carvedilol effects on both function and structure of kidney in diabetic nephropathy treatment were evaluated. Diabetes was induced by injection of streptozotocin (STZ) intravenously in rats and three groups including control, diabetic, and treatment with carvedilol were considered. Biochemical parameters such as, blood glucose level, BUN, creatinine, uric acid, Na(+), K(+) was determined. Results showed that glucose (516 to 291 mg/dl), BUN (42 to 21.67 mg/dl), creatinine (0.75 to 0.6 mg/dl), uric acid (4.45 to 1.36 mg/dl), and K(+) (7.433 to 5.433 mEq/l) level reduced. Decrease in glucose, BUN, creatinine, uric acid, and K(+) and increase in Na(+) level (138 to 146.33 mEq/l) confirmed therapeutic effect of carvedilol. Furthermore, the histopathological study was done for each group. Histopathological results confirmed the data obtained by biochemical parameters. For further investigation, SPECT imaging with (99m)Tc-DMSA, which is a gold standard in diabetic nephropathy detection, was done. SPECT imaging showed that accumulation of (99m)Tc-DMSA was increased in treated group (5 to 25 kcpm) which means the improvement in renal structure in the treated group compare to the diabetic group (5 kcpm). Finally, obtained results confirmed our hypothesis that carvedilol had a therapeutic effect on diabetic nephropathy.
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spelling pubmed-92534812022-07-06 Therapeutic effect of antihypertensive drug on diabetic nephropathy: Functional and structural kidney investigation Masoumeh Ghoreishi, Seyedeh Amiri, Mehrangiz Shabestani Monfared, Ali Hamidi, Faezeh Najafzadehvarzi, Hossein Saudi J Biol Sci Original Article Due to the growth of diabetic mellitus (DM) and diabetic nephropathy as a significant complication for diabetic patients, study on effective treatment with fewer side effects has been fascinated. In this study for the first time carvedilol effects on both function and structure of kidney in diabetic nephropathy treatment were evaluated. Diabetes was induced by injection of streptozotocin (STZ) intravenously in rats and three groups including control, diabetic, and treatment with carvedilol were considered. Biochemical parameters such as, blood glucose level, BUN, creatinine, uric acid, Na(+), K(+) was determined. Results showed that glucose (516 to 291 mg/dl), BUN (42 to 21.67 mg/dl), creatinine (0.75 to 0.6 mg/dl), uric acid (4.45 to 1.36 mg/dl), and K(+) (7.433 to 5.433 mEq/l) level reduced. Decrease in glucose, BUN, creatinine, uric acid, and K(+) and increase in Na(+) level (138 to 146.33 mEq/l) confirmed therapeutic effect of carvedilol. Furthermore, the histopathological study was done for each group. Histopathological results confirmed the data obtained by biochemical parameters. For further investigation, SPECT imaging with (99m)Tc-DMSA, which is a gold standard in diabetic nephropathy detection, was done. SPECT imaging showed that accumulation of (99m)Tc-DMSA was increased in treated group (5 to 25 kcpm) which means the improvement in renal structure in the treated group compare to the diabetic group (5 kcpm). Finally, obtained results confirmed our hypothesis that carvedilol had a therapeutic effect on diabetic nephropathy. Elsevier 2022-08 2022-06-20 /pmc/articles/PMC9253481/ /pubmed/35800144 http://dx.doi.org/10.1016/j.sjbs.2022.103353 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Masoumeh Ghoreishi, Seyedeh
Amiri, Mehrangiz
Shabestani Monfared, Ali
Hamidi, Faezeh
Najafzadehvarzi, Hossein
Therapeutic effect of antihypertensive drug on diabetic nephropathy: Functional and structural kidney investigation
title Therapeutic effect of antihypertensive drug on diabetic nephropathy: Functional and structural kidney investigation
title_full Therapeutic effect of antihypertensive drug on diabetic nephropathy: Functional and structural kidney investigation
title_fullStr Therapeutic effect of antihypertensive drug on diabetic nephropathy: Functional and structural kidney investigation
title_full_unstemmed Therapeutic effect of antihypertensive drug on diabetic nephropathy: Functional and structural kidney investigation
title_short Therapeutic effect of antihypertensive drug on diabetic nephropathy: Functional and structural kidney investigation
title_sort therapeutic effect of antihypertensive drug on diabetic nephropathy: functional and structural kidney investigation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253481/
https://www.ncbi.nlm.nih.gov/pubmed/35800144
http://dx.doi.org/10.1016/j.sjbs.2022.103353
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