Cargando…
Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca(2+) release from the ER
Uncoupling protein 2 (UCP2), a mitochondrial protein, is known to be upregulated in pancreatic islets of patients with type 2 diabetes (T2DM); however, the pathological significance of this increase in UCP2 expression is unclear. In this study, we highlight the molecular link between the increase in...
Autores principales: | Inoue, Ryota, Tsuno, Takahiro, Togashi, Yu, Okuyama, Tomoko, Sato, Aoi, Nishiyama, Kuniyuki, Kyohara, Mayu, Li, Jinghe, Fukushima, Setsuko, Kin, Tatsuya, Miyashita, Daisuke, Shiba, Yusuke, Atobe, Yoshitoshi, Kiyonari, Hiroshi, Bando, Kana, Shapiro, A.M. James, Funakoshi, Kengo, Kulkarni, Rohit N., Terauchi, Yasuo, Shirakawa, Jun |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253497/ https://www.ncbi.nlm.nih.gov/pubmed/35800776 http://dx.doi.org/10.1016/j.isci.2022.104603 |
Ejemplares similares
-
Association between circulating SerpinB1 levels and insulin sensitivity in Japanese with type 2 diabetes: A single-center, cross-sectional, observational study
por: Kyohara, Mayu, et al.
Publicado: (2022) -
Soluble EGFR, a hepatokine, and adipsin, an adipokine, are biomarkers correlated with distinct aspects of insulin resistance in type 2 diabetes subjects
por: Kyohara, Mayu, et al.
Publicado: (2020) -
Protective effects of S100A8 on sepsis mortality: Links to sepsis risk in obesity and diabetes
por: Miyashita, Daisuke, et al.
Publicado: (2022) -
Abdominal aortic calcification is associated with Fibrosis‐4 index and low body mass index in type 2 diabetes patients: A retrospective cross‐sectional study
por: Togashi, Yu, et al.
Publicado: (2022) -
Immediate Glucose-Lowering Effect After the First Administration of Dulaglutide: A Retrospective, Single-Center, Observational Study
por: Terui, Sakiko, et al.
Publicado: (2021)