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An Optimized Miniaturized Ultrasound Transducer for Transcranial Neuromodulation

Transcranial ultrasound stimulation (TUS) is a young neuromodulation technology, which uses ultrasound to achieve non-invasive stimulation or inhibition of deep intracranial brain regions, with the advantages of non-invasive, deep penetration, and high resolution. It is widely considered to be one o...

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Autores principales: Hou, Chenxue, Wu, Yan, Fei, Chunlong, Qiu, Zhihai, Li, Zhaoxi, Sun, Xinhao, Zheng, Chenxi, Yang, Yintang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253503/
https://www.ncbi.nlm.nih.gov/pubmed/35801172
http://dx.doi.org/10.3389/fnins.2022.893108
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author Hou, Chenxue
Wu, Yan
Fei, Chunlong
Qiu, Zhihai
Li, Zhaoxi
Sun, Xinhao
Zheng, Chenxi
Yang, Yintang
author_facet Hou, Chenxue
Wu, Yan
Fei, Chunlong
Qiu, Zhihai
Li, Zhaoxi
Sun, Xinhao
Zheng, Chenxi
Yang, Yintang
author_sort Hou, Chenxue
collection PubMed
description Transcranial ultrasound stimulation (TUS) is a young neuromodulation technology, which uses ultrasound to achieve non-invasive stimulation or inhibition of deep intracranial brain regions, with the advantages of non-invasive, deep penetration, and high resolution. It is widely considered to be one of the most promising techniques for probing brain function and treating brain diseases. In preclinical studies, developing miniaturized transducers to facilitate neuromodulation in freely moving small animals is critical for understanding the mechanism and exploring potential applications. In this article, a miniaturized transducer with a half-concave structure is proposed. Based on the finite element simulation models established by PZFlex software, several ultrasound transducers with different concave curvatures were designed and analyzed. Based on the simulation results, half-concave focused ultrasonic transducers with curvature radii of 5 mm and 7.5 mm were fabricated. Additionally, the emission acoustic fields of the ultrasonic transducers with different structures were characterized at their thickness resonance frequencies of 1 MHz using a multifunctional ultrasonic test platform built in the laboratory. To verify the practical ability for neuromodulation, different ultrasound transducers were used to induce muscle activity in mice. As a result, the stimulation success rates were (32 ± 10)%, (65 ± 8)%, and (84 ± 7)%, respectively, by using flat, #7, and #5 transducers, which shows the simulation and experimental results have a good agreement and that the miniaturized half-concave transducer could effectively converge the acoustic energy and achieve precise and effective ultrasonic neuromodulation.
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spelling pubmed-92535032022-07-06 An Optimized Miniaturized Ultrasound Transducer for Transcranial Neuromodulation Hou, Chenxue Wu, Yan Fei, Chunlong Qiu, Zhihai Li, Zhaoxi Sun, Xinhao Zheng, Chenxi Yang, Yintang Front Neurosci Neuroscience Transcranial ultrasound stimulation (TUS) is a young neuromodulation technology, which uses ultrasound to achieve non-invasive stimulation or inhibition of deep intracranial brain regions, with the advantages of non-invasive, deep penetration, and high resolution. It is widely considered to be one of the most promising techniques for probing brain function and treating brain diseases. In preclinical studies, developing miniaturized transducers to facilitate neuromodulation in freely moving small animals is critical for understanding the mechanism and exploring potential applications. In this article, a miniaturized transducer with a half-concave structure is proposed. Based on the finite element simulation models established by PZFlex software, several ultrasound transducers with different concave curvatures were designed and analyzed. Based on the simulation results, half-concave focused ultrasonic transducers with curvature radii of 5 mm and 7.5 mm were fabricated. Additionally, the emission acoustic fields of the ultrasonic transducers with different structures were characterized at their thickness resonance frequencies of 1 MHz using a multifunctional ultrasonic test platform built in the laboratory. To verify the practical ability for neuromodulation, different ultrasound transducers were used to induce muscle activity in mice. As a result, the stimulation success rates were (32 ± 10)%, (65 ± 8)%, and (84 ± 7)%, respectively, by using flat, #7, and #5 transducers, which shows the simulation and experimental results have a good agreement and that the miniaturized half-concave transducer could effectively converge the acoustic energy and achieve precise and effective ultrasonic neuromodulation. Frontiers Media S.A. 2022-06-21 /pmc/articles/PMC9253503/ /pubmed/35801172 http://dx.doi.org/10.3389/fnins.2022.893108 Text en Copyright © 2022 Hou, Wu, Fei, Qiu, Li, Sun, Zheng and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Hou, Chenxue
Wu, Yan
Fei, Chunlong
Qiu, Zhihai
Li, Zhaoxi
Sun, Xinhao
Zheng, Chenxi
Yang, Yintang
An Optimized Miniaturized Ultrasound Transducer for Transcranial Neuromodulation
title An Optimized Miniaturized Ultrasound Transducer for Transcranial Neuromodulation
title_full An Optimized Miniaturized Ultrasound Transducer for Transcranial Neuromodulation
title_fullStr An Optimized Miniaturized Ultrasound Transducer for Transcranial Neuromodulation
title_full_unstemmed An Optimized Miniaturized Ultrasound Transducer for Transcranial Neuromodulation
title_short An Optimized Miniaturized Ultrasound Transducer for Transcranial Neuromodulation
title_sort optimized miniaturized ultrasound transducer for transcranial neuromodulation
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253503/
https://www.ncbi.nlm.nih.gov/pubmed/35801172
http://dx.doi.org/10.3389/fnins.2022.893108
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