Inhibition of BET Protein Function Suppressed the Overactivation of the Canonical NF-κB Signaling Pathway in 6-OHDA-Lesioned Rat Model of Levodopa-Induced Dyskinesia

BACKGROUND: Neuroinflammation is involved in the mechanisms of levodopa-induced dyskinesia (LID). The canonical NF-κB activation signaling pathway plays a critical role in the neuroinflammation development and BET protein-induced NF-κB-mediated neuroinflammation. The inhibition of the BET protein fu...

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Detalles Bibliográficos
Autores principales: Wan, Ying, Han, Li, Rong, Lu, Yang, Shuyuan, Song, Lu, Wu, Na, Liu, Zhenguo, Gan, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253514/
https://www.ncbi.nlm.nih.gov/pubmed/35801173
http://dx.doi.org/10.3389/fnins.2022.896322

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