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Research Progress in Exosome-Based Nanoscale Drug Carriers in Tumor Therapies
Current antitumor treatment methods have several reported limitations, including multidrug resistance and serious adverse reactions. Targeted drug delivery systems are effective alternatives that can help healthcare providers overcome these limitations. Exosomes can serve as a natural nanoscale drug...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253528/ https://www.ncbi.nlm.nih.gov/pubmed/35800056 http://dx.doi.org/10.3389/fonc.2022.919279 |
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author | Fu, Wei Li, Tingting Chen, Hongbo Zhu, Shu Zhou, Changkai |
author_facet | Fu, Wei Li, Tingting Chen, Hongbo Zhu, Shu Zhou, Changkai |
author_sort | Fu, Wei |
collection | PubMed |
description | Current antitumor treatment methods have several reported limitations, including multidrug resistance and serious adverse reactions. Targeted drug delivery systems are effective alternatives that can help healthcare providers overcome these limitations. Exosomes can serve as a natural nanoscale drug delivery system, with the advantages of high biocompatibility, low immunogenicity, and efficient tumor targetability. In this paper, we discuss the biological characteristics of exosomes, summarize the drug-carrying mechanisms of exosome-based drug delivery systems, and examine the potential role and applicability of exosomes in clinical tumor treatment approaches. This review can be used as a guideline for the future development of exosome-based delivery systems in clinical precision tumor treatment. |
format | Online Article Text |
id | pubmed-9253528 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92535282022-07-06 Research Progress in Exosome-Based Nanoscale Drug Carriers in Tumor Therapies Fu, Wei Li, Tingting Chen, Hongbo Zhu, Shu Zhou, Changkai Front Oncol Oncology Current antitumor treatment methods have several reported limitations, including multidrug resistance and serious adverse reactions. Targeted drug delivery systems are effective alternatives that can help healthcare providers overcome these limitations. Exosomes can serve as a natural nanoscale drug delivery system, with the advantages of high biocompatibility, low immunogenicity, and efficient tumor targetability. In this paper, we discuss the biological characteristics of exosomes, summarize the drug-carrying mechanisms of exosome-based drug delivery systems, and examine the potential role and applicability of exosomes in clinical tumor treatment approaches. This review can be used as a guideline for the future development of exosome-based delivery systems in clinical precision tumor treatment. Frontiers Media S.A. 2022-06-21 /pmc/articles/PMC9253528/ /pubmed/35800056 http://dx.doi.org/10.3389/fonc.2022.919279 Text en Copyright © 2022 Fu, Li, Chen, Zhu and Zhou https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Fu, Wei Li, Tingting Chen, Hongbo Zhu, Shu Zhou, Changkai Research Progress in Exosome-Based Nanoscale Drug Carriers in Tumor Therapies |
title | Research Progress in Exosome-Based Nanoscale Drug Carriers in Tumor Therapies |
title_full | Research Progress in Exosome-Based Nanoscale Drug Carriers in Tumor Therapies |
title_fullStr | Research Progress in Exosome-Based Nanoscale Drug Carriers in Tumor Therapies |
title_full_unstemmed | Research Progress in Exosome-Based Nanoscale Drug Carriers in Tumor Therapies |
title_short | Research Progress in Exosome-Based Nanoscale Drug Carriers in Tumor Therapies |
title_sort | research progress in exosome-based nanoscale drug carriers in tumor therapies |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253528/ https://www.ncbi.nlm.nih.gov/pubmed/35800056 http://dx.doi.org/10.3389/fonc.2022.919279 |
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