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Research Progress in Exosome-Based Nanoscale Drug Carriers in Tumor Therapies

Current antitumor treatment methods have several reported limitations, including multidrug resistance and serious adverse reactions. Targeted drug delivery systems are effective alternatives that can help healthcare providers overcome these limitations. Exosomes can serve as a natural nanoscale drug...

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Detalles Bibliográficos
Autores principales: Fu, Wei, Li, Tingting, Chen, Hongbo, Zhu, Shu, Zhou, Changkai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253528/
https://www.ncbi.nlm.nih.gov/pubmed/35800056
http://dx.doi.org/10.3389/fonc.2022.919279
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author Fu, Wei
Li, Tingting
Chen, Hongbo
Zhu, Shu
Zhou, Changkai
author_facet Fu, Wei
Li, Tingting
Chen, Hongbo
Zhu, Shu
Zhou, Changkai
author_sort Fu, Wei
collection PubMed
description Current antitumor treatment methods have several reported limitations, including multidrug resistance and serious adverse reactions. Targeted drug delivery systems are effective alternatives that can help healthcare providers overcome these limitations. Exosomes can serve as a natural nanoscale drug delivery system, with the advantages of high biocompatibility, low immunogenicity, and efficient tumor targetability. In this paper, we discuss the biological characteristics of exosomes, summarize the drug-carrying mechanisms of exosome-based drug delivery systems, and examine the potential role and applicability of exosomes in clinical tumor treatment approaches. This review can be used as a guideline for the future development of exosome-based delivery systems in clinical precision tumor treatment.
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spelling pubmed-92535282022-07-06 Research Progress in Exosome-Based Nanoscale Drug Carriers in Tumor Therapies Fu, Wei Li, Tingting Chen, Hongbo Zhu, Shu Zhou, Changkai Front Oncol Oncology Current antitumor treatment methods have several reported limitations, including multidrug resistance and serious adverse reactions. Targeted drug delivery systems are effective alternatives that can help healthcare providers overcome these limitations. Exosomes can serve as a natural nanoscale drug delivery system, with the advantages of high biocompatibility, low immunogenicity, and efficient tumor targetability. In this paper, we discuss the biological characteristics of exosomes, summarize the drug-carrying mechanisms of exosome-based drug delivery systems, and examine the potential role and applicability of exosomes in clinical tumor treatment approaches. This review can be used as a guideline for the future development of exosome-based delivery systems in clinical precision tumor treatment. Frontiers Media S.A. 2022-06-21 /pmc/articles/PMC9253528/ /pubmed/35800056 http://dx.doi.org/10.3389/fonc.2022.919279 Text en Copyright © 2022 Fu, Li, Chen, Zhu and Zhou https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Fu, Wei
Li, Tingting
Chen, Hongbo
Zhu, Shu
Zhou, Changkai
Research Progress in Exosome-Based Nanoscale Drug Carriers in Tumor Therapies
title Research Progress in Exosome-Based Nanoscale Drug Carriers in Tumor Therapies
title_full Research Progress in Exosome-Based Nanoscale Drug Carriers in Tumor Therapies
title_fullStr Research Progress in Exosome-Based Nanoscale Drug Carriers in Tumor Therapies
title_full_unstemmed Research Progress in Exosome-Based Nanoscale Drug Carriers in Tumor Therapies
title_short Research Progress in Exosome-Based Nanoscale Drug Carriers in Tumor Therapies
title_sort research progress in exosome-based nanoscale drug carriers in tumor therapies
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253528/
https://www.ncbi.nlm.nih.gov/pubmed/35800056
http://dx.doi.org/10.3389/fonc.2022.919279
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