Cargando…

Posttranslational Regulation of Inflammasomes, Its Potential as Biomarkers and in the Identification of Novel Drugs Targets

In this review, we have summarized classical post-translational modifications (PTMs) such as phosphorylation, ubiquitylation, and SUMOylation of the different components of one of the most studied NLRP3, and other emerging inflammasomes. We will highlight how the discovery of these modifications hav...

Descripción completa

Detalles Bibliográficos
Autores principales: Nanda, Sambit K., Vollmer, Stefan, Perez-Oliva, Ana B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253692/
https://www.ncbi.nlm.nih.gov/pubmed/35800898
http://dx.doi.org/10.3389/fcell.2022.887533
_version_ 1784740549259952128
author Nanda, Sambit K.
Vollmer, Stefan
Perez-Oliva, Ana B.
author_facet Nanda, Sambit K.
Vollmer, Stefan
Perez-Oliva, Ana B.
author_sort Nanda, Sambit K.
collection PubMed
description In this review, we have summarized classical post-translational modifications (PTMs) such as phosphorylation, ubiquitylation, and SUMOylation of the different components of one of the most studied NLRP3, and other emerging inflammasomes. We will highlight how the discovery of these modifications have provided mechanistic insight into the biology, function, and regulation of these multiprotein complexes not only in the context of the innate immune system but also in adaptive immunity, hematopoiesis, bone marrow transplantation, as well and their role in human diseases. We have also collected available information concerning less-studied modifications such as acetylation, ADP-ribosylation, nitrosylation, prenylation, citrullination, and emphasized their relevance in the regulation of inflammasome complex formation. We have described disease-associated mutations affecting PTMs of inflammasome components. Finally, we have discussed how a deeper understanding of different PTMs can help the development of biomarkers and identification of novel drug targets to treat diseases caused by the malfunctioning of inflammasomes.
format Online
Article
Text
id pubmed-9253692
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-92536922022-07-06 Posttranslational Regulation of Inflammasomes, Its Potential as Biomarkers and in the Identification of Novel Drugs Targets Nanda, Sambit K. Vollmer, Stefan Perez-Oliva, Ana B. Front Cell Dev Biol Cell and Developmental Biology In this review, we have summarized classical post-translational modifications (PTMs) such as phosphorylation, ubiquitylation, and SUMOylation of the different components of one of the most studied NLRP3, and other emerging inflammasomes. We will highlight how the discovery of these modifications have provided mechanistic insight into the biology, function, and regulation of these multiprotein complexes not only in the context of the innate immune system but also in adaptive immunity, hematopoiesis, bone marrow transplantation, as well and their role in human diseases. We have also collected available information concerning less-studied modifications such as acetylation, ADP-ribosylation, nitrosylation, prenylation, citrullination, and emphasized their relevance in the regulation of inflammasome complex formation. We have described disease-associated mutations affecting PTMs of inflammasome components. Finally, we have discussed how a deeper understanding of different PTMs can help the development of biomarkers and identification of novel drug targets to treat diseases caused by the malfunctioning of inflammasomes. Frontiers Media S.A. 2022-06-21 /pmc/articles/PMC9253692/ /pubmed/35800898 http://dx.doi.org/10.3389/fcell.2022.887533 Text en Copyright © 2022 Nanda, Vollmer and Perez-Oliva. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Nanda, Sambit K.
Vollmer, Stefan
Perez-Oliva, Ana B.
Posttranslational Regulation of Inflammasomes, Its Potential as Biomarkers and in the Identification of Novel Drugs Targets
title Posttranslational Regulation of Inflammasomes, Its Potential as Biomarkers and in the Identification of Novel Drugs Targets
title_full Posttranslational Regulation of Inflammasomes, Its Potential as Biomarkers and in the Identification of Novel Drugs Targets
title_fullStr Posttranslational Regulation of Inflammasomes, Its Potential as Biomarkers and in the Identification of Novel Drugs Targets
title_full_unstemmed Posttranslational Regulation of Inflammasomes, Its Potential as Biomarkers and in the Identification of Novel Drugs Targets
title_short Posttranslational Regulation of Inflammasomes, Its Potential as Biomarkers and in the Identification of Novel Drugs Targets
title_sort posttranslational regulation of inflammasomes, its potential as biomarkers and in the identification of novel drugs targets
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253692/
https://www.ncbi.nlm.nih.gov/pubmed/35800898
http://dx.doi.org/10.3389/fcell.2022.887533
work_keys_str_mv AT nandasambitk posttranslationalregulationofinflammasomesitspotentialasbiomarkersandintheidentificationofnoveldrugstargets
AT vollmerstefan posttranslationalregulationofinflammasomesitspotentialasbiomarkersandintheidentificationofnoveldrugstargets
AT perezolivaanab posttranslationalregulationofinflammasomesitspotentialasbiomarkersandintheidentificationofnoveldrugstargets