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The immune checkpoint ICOSLG is a relapse-predicting biomarker and therapeutic target in infant t(4;11) acute lymphoblastic leukemia

The most frequent genetic aberration leading to infant ALL (iALL) is the chromosomal translocation t(4;11), generating the fusion oncogenes KMT2A:AFF1 and AFF1:KMT2A, respectively. KMT2A-r iALL displays a dismal prognosis through high relapse rates and relapse-associated mortality. Relapse occurs fr...

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Detalles Bibliográficos
Autores principales:	Külp, Marius, Siemund, Anna Lena, Larghero, Patrizia, Dietz, Alissa, Alten, Julia, Cario, Gunnar, Eckert, Cornelia, Caye-Eude, Aurélie, Cavé, Hélène, Bardini, Michela, Cazzaniga, Giovanni, De Lorenzo, Paola, Valsecchi, Maria Grazia, Diehl, Laura, Bonig, Halvard, Meyer, Claus, Marschalek, Rolf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253708/ https://www.ncbi.nlm.nih.gov/pubmed/35800767 http://dx.doi.org/10.1016/j.isci.2022.104613

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