Myeloid cell‐specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation

Targeting myeloid cells, especially microglia, for the treatment of neuroinflammatory diseases such as multiple sclerosis (MS), is underappreciated. Our in silico drug screening reveals topoisomerase 1 (TOP1) inhibitors as promising drug candidates for microglial modulation. We show that TOP1 is hig...

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Detalles Bibliográficos
Autores principales: Zhu, Keying, Wang, Yang, Sarlus, Heela, Geng, Keyi, Nutma, Erik, Sun, Jingxian, Kung, Shin‐Yu, Bay, Cindy, Han, Jinming, Min, Jin‐Hong, Benito‐Cuesta, Irene, Lund, Harald, Amor, Sandra, Wang, Jun, Zhang, Xing‐Mei, Kutter, Claudia, Guerreiro‐Cacais, André Ortlieb, Högberg, Björn, Harris, Robert A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253741/
https://www.ncbi.nlm.nih.gov/pubmed/35593064
http://dx.doi.org/10.15252/embr.202154499

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