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Diacylglycerols interact with the L2 lipidation site in TRPC3 to induce a sensitized channel state

Coordination of lipids within transient receptor potential canonical channels (TRPCs) is essential for their Ca(2+) signaling function. Single particle cryo‐EM studies identified two lipid interaction sites, designated L1 and L2, which are proposed to accommodate diacylglycerols (DAGs). To explore t...

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Detalles Bibliográficos
Autores principales:	Erkan‐Candag, Hazel, Clarke, Amy, Tiapko, Oleksandra, Gsell, Mathias AF, Stockner, Thomas, Groschner, Klaus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253791/ https://www.ncbi.nlm.nih.gov/pubmed/35604352 http://dx.doi.org/10.15252/embr.202154276

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