Molecular lesions in alleles of the Caenorhabditis elegans lin-11 gene

The LIM homeodomain transcription factor LIN-11 is a key regulator of vulva, uterine, and neuron development in C. elegans. Multiple alleles of lin-11 are available, but none had been sequenced. We found that the reference allele, n389, is a 15900 bp deletion that also affects two other protein-codi...

Descripción completa

Detalles Bibliográficos
Autores principales: Young, Adrie F., Schmidt, Helen F., Sundaram, Meera V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2022
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253893/
https://www.ncbi.nlm.nih.gov/pubmed/35800971
http://dx.doi.org/10.17912/micropub.biology.000589
Descripción
Sumario:The LIM homeodomain transcription factor LIN-11 is a key regulator of vulva, uterine, and neuron development in C. elegans. Multiple alleles of lin-11 are available, but none had been sequenced. We found that the reference allele, n389, is a 15900 bp deletion that also affects two other protein-coding genes, ZC247.1 and ZC247.2. The frequently used n566 allele is a 288bp deletion located in an intron and affecting the splice acceptor site.

Ejemplares similares