Molecular lesions in alleles of the Caenorhabditis elegans lin-11 gene

The LIM homeodomain transcription factor LIN-11 is a key regulator of vulva, uterine, and neuron development in C. elegans. Multiple alleles of lin-11 are available, but none had been sequenced. We found that the reference allele, n389, is a 15900 bp deletion that also affects two other protein-codi...

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Autores principales: Young, Adrie F., Schmidt, Helen F., Sundaram, Meera V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2022
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253893/
https://www.ncbi.nlm.nih.gov/pubmed/35800971
http://dx.doi.org/10.17912/micropub.biology.000589
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author Young, Adrie F.
Schmidt, Helen F.
Sundaram, Meera V.
author_facet Young, Adrie F.
Schmidt, Helen F.
Sundaram, Meera V.
author_sort Young, Adrie F.
collection PubMed
description The LIM homeodomain transcription factor LIN-11 is a key regulator of vulva, uterine, and neuron development in C. elegans. Multiple alleles of lin-11 are available, but none had been sequenced. We found that the reference allele, n389, is a 15900 bp deletion that also affects two other protein-coding genes, ZC247.1 and ZC247.2. The frequently used n566 allele is a 288bp deletion located in an intron and affecting the splice acceptor site.
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spelling pubmed-92538932022-07-06 Molecular lesions in alleles of the Caenorhabditis elegans lin-11 gene Young, Adrie F. Schmidt, Helen F. Sundaram, Meera V. MicroPubl Biol New Finding The LIM homeodomain transcription factor LIN-11 is a key regulator of vulva, uterine, and neuron development in C. elegans. Multiple alleles of lin-11 are available, but none had been sequenced. We found that the reference allele, n389, is a 15900 bp deletion that also affects two other protein-coding genes, ZC247.1 and ZC247.2. The frequently used n566 allele is a 288bp deletion located in an intron and affecting the splice acceptor site. Caltech Library 2022-06-20 /pmc/articles/PMC9253893/ /pubmed/35800971 http://dx.doi.org/10.17912/micropub.biology.000589 Text en Copyright: © 2022 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle New Finding
Young, Adrie F.
Schmidt, Helen F.
Sundaram, Meera V.
Molecular lesions in alleles of the Caenorhabditis elegans lin-11 gene
title Molecular lesions in alleles of the Caenorhabditis elegans lin-11 gene
title_full Molecular lesions in alleles of the Caenorhabditis elegans lin-11 gene
title_fullStr Molecular lesions in alleles of the Caenorhabditis elegans lin-11 gene
title_full_unstemmed Molecular lesions in alleles of the Caenorhabditis elegans lin-11 gene
title_short Molecular lesions in alleles of the Caenorhabditis elegans lin-11 gene
title_sort molecular lesions in alleles of the caenorhabditis elegans lin-11 gene
topic New Finding
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253893/
https://www.ncbi.nlm.nih.gov/pubmed/35800971
http://dx.doi.org/10.17912/micropub.biology.000589
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