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COVID-19 disease severity in persons infected with the Omicron variant compared with the Delta variant in Qatar
BACKGROUND: Understanding the disease severity associated with the Omicron variant of the SARS-CoV-2 virus is important in determining appropriate management strategies at the individual and population levels. We determined the severity of SARS-CoV-2 infection in persons infected with the Omicron vs...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Society of Global Health
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253930/ https://www.ncbi.nlm.nih.gov/pubmed/35788085 http://dx.doi.org/10.7189/jogh.12.05032 |
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author | Butt, Adeel A Dargham, Soha R Tang, Patrick Chemaitelly, Hiam Hasan, Mohammad R Coyle, Peter V Kaleeckal, Anvar H Latif, Ali Nizar Loka, Srusvin Shaik, Riyazuddin M Zaqout, Ahmed Almaslamani, Muna A Al Khal, Abdullatif Bertollini, Roberto Abou-Samra, Abdul-Badi Abu-Raddad, Laith J |
author_facet | Butt, Adeel A Dargham, Soha R Tang, Patrick Chemaitelly, Hiam Hasan, Mohammad R Coyle, Peter V Kaleeckal, Anvar H Latif, Ali Nizar Loka, Srusvin Shaik, Riyazuddin M Zaqout, Ahmed Almaslamani, Muna A Al Khal, Abdullatif Bertollini, Roberto Abou-Samra, Abdul-Badi Abu-Raddad, Laith J |
author_sort | Butt, Adeel A |
collection | PubMed |
description | BACKGROUND: Understanding the disease severity associated with the Omicron variant of the SARS-CoV-2 virus is important in determining appropriate management strategies at the individual and population levels. We determined the severity of SARS-CoV-2 infection in persons infected with the Omicron vs the Delta variant. METHODS: We identified individuals with SARS-CoV-2 infection with Delta and propensity-score matched controls with Omicron variant infection from the National COVID-19 Database in Qatar. We excluded temporary visitors to Qatar, those with a prior documented infection, those ≤18 years old, and those with <14 days of follow up after the index test positive date. We determined the rates of admission to the hospital, admission to intensive care unit, mechanical ventilation, or death among those infected with the Delta or Omicron variants. RESULTS: Among 9763 cases infected with the Delta variant and 11 310 cases infected with the Omicron variant, we identified 3926 propensity-score matched pairs. Among 3926 Delta infected, 3259 (83.0%) had mild, 633 (16.1%) had moderate and 34 (0.9%) had severe/critical disease. Among 3926 Omicron infected, 3866 (98.5%) had mild, 59 (1.5%) had moderate, and only 1 had severe/critical disease (overall P < 0.001). Factors associated with less moderate or severe/critical disease included infection with Omicron variant (aOR = 0.06; confidence interval (CI) = 0.05-0.09) and vaccination including a booster (aOR = 0.30; 95% CI = 0.09-0.99). CONCLUSIONS: Omicron variant infection is associated with significantly lower severity of disease compared with the Delta variant. Vaccination continues to offer strong protection against severe/critical disease. |
format | Online Article Text |
id | pubmed-9253930 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | International Society of Global Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-92539302022-07-08 COVID-19 disease severity in persons infected with the Omicron variant compared with the Delta variant in Qatar Butt, Adeel A Dargham, Soha R Tang, Patrick Chemaitelly, Hiam Hasan, Mohammad R Coyle, Peter V Kaleeckal, Anvar H Latif, Ali Nizar Loka, Srusvin Shaik, Riyazuddin M Zaqout, Ahmed Almaslamani, Muna A Al Khal, Abdullatif Bertollini, Roberto Abou-Samra, Abdul-Badi Abu-Raddad, Laith J J Glob Health Research Theme 1: COVID-19 Pandemic BACKGROUND: Understanding the disease severity associated with the Omicron variant of the SARS-CoV-2 virus is important in determining appropriate management strategies at the individual and population levels. We determined the severity of SARS-CoV-2 infection in persons infected with the Omicron vs the Delta variant. METHODS: We identified individuals with SARS-CoV-2 infection with Delta and propensity-score matched controls with Omicron variant infection from the National COVID-19 Database in Qatar. We excluded temporary visitors to Qatar, those with a prior documented infection, those ≤18 years old, and those with <14 days of follow up after the index test positive date. We determined the rates of admission to the hospital, admission to intensive care unit, mechanical ventilation, or death among those infected with the Delta or Omicron variants. RESULTS: Among 9763 cases infected with the Delta variant and 11 310 cases infected with the Omicron variant, we identified 3926 propensity-score matched pairs. Among 3926 Delta infected, 3259 (83.0%) had mild, 633 (16.1%) had moderate and 34 (0.9%) had severe/critical disease. Among 3926 Omicron infected, 3866 (98.5%) had mild, 59 (1.5%) had moderate, and only 1 had severe/critical disease (overall P < 0.001). Factors associated with less moderate or severe/critical disease included infection with Omicron variant (aOR = 0.06; confidence interval (CI) = 0.05-0.09) and vaccination including a booster (aOR = 0.30; 95% CI = 0.09-0.99). CONCLUSIONS: Omicron variant infection is associated with significantly lower severity of disease compared with the Delta variant. Vaccination continues to offer strong protection against severe/critical disease. International Society of Global Health 2022-07-06 /pmc/articles/PMC9253930/ /pubmed/35788085 http://dx.doi.org/10.7189/jogh.12.05032 Text en Copyright © 2022 by the Journal of Global Health. All rights reserved. https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License. |
spellingShingle | Research Theme 1: COVID-19 Pandemic Butt, Adeel A Dargham, Soha R Tang, Patrick Chemaitelly, Hiam Hasan, Mohammad R Coyle, Peter V Kaleeckal, Anvar H Latif, Ali Nizar Loka, Srusvin Shaik, Riyazuddin M Zaqout, Ahmed Almaslamani, Muna A Al Khal, Abdullatif Bertollini, Roberto Abou-Samra, Abdul-Badi Abu-Raddad, Laith J COVID-19 disease severity in persons infected with the Omicron variant compared with the Delta variant in Qatar |
title | COVID-19 disease severity in persons infected with the Omicron variant compared with the Delta variant in Qatar |
title_full | COVID-19 disease severity in persons infected with the Omicron variant compared with the Delta variant in Qatar |
title_fullStr | COVID-19 disease severity in persons infected with the Omicron variant compared with the Delta variant in Qatar |
title_full_unstemmed | COVID-19 disease severity in persons infected with the Omicron variant compared with the Delta variant in Qatar |
title_short | COVID-19 disease severity in persons infected with the Omicron variant compared with the Delta variant in Qatar |
title_sort | covid-19 disease severity in persons infected with the omicron variant compared with the delta variant in qatar |
topic | Research Theme 1: COVID-19 Pandemic |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253930/ https://www.ncbi.nlm.nih.gov/pubmed/35788085 http://dx.doi.org/10.7189/jogh.12.05032 |
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