Hepatocyte cholesterol content modulates glucagon receptor signalling

OBJECTIVE: To determine whether glucagon receptor (GCGR) actions are modulated by cellular cholesterol levels. METHODS: We determined the effects of experimental cholesterol depletion and loading on glucagon-mediated cAMP production, ligand internalisation and glucose production in human hepatoma ce...

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Detalles Bibliográficos
Autores principales: McGlone, Emma Rose, Ansell, T. Bertie, Dunsterville, Cecilia, Song, Wanling, Carling, David, Tomas, Alejandra, Bloom, Stephen R., Sansom, Mark S.P., Tan, Tricia, Jones, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254120/
https://www.ncbi.nlm.nih.gov/pubmed/35718339
http://dx.doi.org/10.1016/j.molmet.2022.101530

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254120/
https://www.ncbi.nlm.nih.gov/pubmed/35718339
http://dx.doi.org/10.1016/j.molmet.2022.101530

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