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Primary gastric dedifferentiated liposarcoma resected endoscopically: A case report

BACKGROUND: Liposarcoma is one of the most common adult mesenchymal tumors but is uncommon in the gastrointestinal tract and extremely rare in the stomach. Furthermore, the histological subtypes of liposarcoma usually reported in the stomach are well-differentiated or myxoid, and few reports have be...

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Autores principales: Cho, Joon Hyun, Byeon, Jun Hyeon, Lee, Si Hyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254141/
https://www.ncbi.nlm.nih.gov/pubmed/35949354
http://dx.doi.org/10.3748/wjg.v28.i23.2625
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author Cho, Joon Hyun
Byeon, Jun Hyeon
Lee, Si Hyung
author_facet Cho, Joon Hyun
Byeon, Jun Hyeon
Lee, Si Hyung
author_sort Cho, Joon Hyun
collection PubMed
description BACKGROUND: Liposarcoma is one of the most common adult mesenchymal tumors but is uncommon in the gastrointestinal tract and extremely rare in the stomach. Furthermore, the histological subtypes of liposarcoma usually reported in the stomach are well-differentiated or myxoid, and few reports have been issued on small-sized gastric liposarcomas resected endoscopically and followed up. Herein, we report a case of primary gastric dedifferentiated liposarcoma (DL) that was resected endoscopically. CASE SUMMARY: A 67-year-old female Korean patient was referred to our institution for further evaluation of a gastric submucosal tumor (SMT) located in the lesser curvature of the gastric body by esophagogastroduodenoscopy. Endoscopic ultrasound revealed a well-circumscribed, slightly heterogeneous, isoechoic, 17 mm × 10 mm sized mass originating from the third sonographic layer. Computed tomography showed no evidence of significant lymph node enlargement or distant metastasis. Endoscopic resection was undertaken using the snare resection technique after mucosal precutting to provide a definitive histopathologic diagnosis, which proved to be consistent with DL, based on its morphology and the immunoexpressions of MDM2 and CDK4. The patient was planned for surgery because the deep resection margin was positive for malignancy. After declining any invasive procedure or adjuvant treatment, the patient was placed under close follow-up, and at one year after endoscopic resection, remained disease free. CONCLUSION: This is the first reported case of a small primary gastric DL resected endoscopically and followed up. This report demonstrates that when diagnosis of a SMT is uncertain, the use of invasive techniques, including endoscopic resection, should be considered.
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spelling pubmed-92541412022-08-09 Primary gastric dedifferentiated liposarcoma resected endoscopically: A case report Cho, Joon Hyun Byeon, Jun Hyeon Lee, Si Hyung World J Gastroenterol Case Report BACKGROUND: Liposarcoma is one of the most common adult mesenchymal tumors but is uncommon in the gastrointestinal tract and extremely rare in the stomach. Furthermore, the histological subtypes of liposarcoma usually reported in the stomach are well-differentiated or myxoid, and few reports have been issued on small-sized gastric liposarcomas resected endoscopically and followed up. Herein, we report a case of primary gastric dedifferentiated liposarcoma (DL) that was resected endoscopically. CASE SUMMARY: A 67-year-old female Korean patient was referred to our institution for further evaluation of a gastric submucosal tumor (SMT) located in the lesser curvature of the gastric body by esophagogastroduodenoscopy. Endoscopic ultrasound revealed a well-circumscribed, slightly heterogeneous, isoechoic, 17 mm × 10 mm sized mass originating from the third sonographic layer. Computed tomography showed no evidence of significant lymph node enlargement or distant metastasis. Endoscopic resection was undertaken using the snare resection technique after mucosal precutting to provide a definitive histopathologic diagnosis, which proved to be consistent with DL, based on its morphology and the immunoexpressions of MDM2 and CDK4. The patient was planned for surgery because the deep resection margin was positive for malignancy. After declining any invasive procedure or adjuvant treatment, the patient was placed under close follow-up, and at one year after endoscopic resection, remained disease free. CONCLUSION: This is the first reported case of a small primary gastric DL resected endoscopically and followed up. This report demonstrates that when diagnosis of a SMT is uncertain, the use of invasive techniques, including endoscopic resection, should be considered. Baishideng Publishing Group Inc 2022-06-21 2022-06-21 /pmc/articles/PMC9254141/ /pubmed/35949354 http://dx.doi.org/10.3748/wjg.v28.i23.2625 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Case Report
Cho, Joon Hyun
Byeon, Jun Hyeon
Lee, Si Hyung
Primary gastric dedifferentiated liposarcoma resected endoscopically: A case report
title Primary gastric dedifferentiated liposarcoma resected endoscopically: A case report
title_full Primary gastric dedifferentiated liposarcoma resected endoscopically: A case report
title_fullStr Primary gastric dedifferentiated liposarcoma resected endoscopically: A case report
title_full_unstemmed Primary gastric dedifferentiated liposarcoma resected endoscopically: A case report
title_short Primary gastric dedifferentiated liposarcoma resected endoscopically: A case report
title_sort primary gastric dedifferentiated liposarcoma resected endoscopically: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254141/
https://www.ncbi.nlm.nih.gov/pubmed/35949354
http://dx.doi.org/10.3748/wjg.v28.i23.2625
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