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Hepatic epithelioid hemangioendothelioma after thirteen years’ follow-up: A case report and review of literature
BACKGROUND: Hepatic epithelioid hemangioendothelioma (EHE) is a rare vascular endothelial cell tumor of the liver, consisting of epithelioid and histiocyte-like vascular endothelial cells in mucus or a fibrotic matrix. Immunohistochemistry is usually positive for vascular markers, such as factor VII...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Baishideng Publishing Group Inc
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254202/ https://www.ncbi.nlm.nih.gov/pubmed/35949854 http://dx.doi.org/10.12998/wjcc.v10.i18.6119 |
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author | Mo, Wei-Fang Tong, Yu-Ling |
author_facet | Mo, Wei-Fang Tong, Yu-Ling |
author_sort | Mo, Wei-Fang |
collection | PubMed |
description | BACKGROUND: Hepatic epithelioid hemangioendothelioma (EHE) is a rare vascular endothelial cell tumor of the liver, consisting of epithelioid and histiocyte-like vascular endothelial cells in mucus or a fibrotic matrix. Immunohistochemistry is usually positive for vascular markers, such as factor VIII-related antigen, CD31, and CD34. Hepatic EHE can have a varied clinical course; treatment includes liver transplantation, liver resection, chemotherapy, and radiation therapy. CASE SUMMARY: A 46-year-old woman with abdominal discomfort and elevated serum carcinoembryonic antigen was found to have multiple low-density lesions in the liver and lung on computed tomography (CT) evaluation. An ultrasound-guided fine needle aspiration biopsy revealed a fibrous stroma with dendritic cells, containing intracellular vacuoles. Immunohistochemical staining found that the tumor cells were positive for CD34, CD31, and factor VIII-related antigen. The patient received four courses of combined chemotherapy and was followed-up for 13 years, at which time the patient was in stable condition without disease progression and a confined neoplasm, as evidenced by CT scans. CONCLUSION: The histology and immunohistochemical characteristics of hepatic EHE are well described. Chemotherapy may be effective in patients with extrahepatic lesions. |
format | Online Article Text |
id | pubmed-9254202 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-92542022022-08-09 Hepatic epithelioid hemangioendothelioma after thirteen years’ follow-up: A case report and review of literature Mo, Wei-Fang Tong, Yu-Ling World J Clin Cases Case Report BACKGROUND: Hepatic epithelioid hemangioendothelioma (EHE) is a rare vascular endothelial cell tumor of the liver, consisting of epithelioid and histiocyte-like vascular endothelial cells in mucus or a fibrotic matrix. Immunohistochemistry is usually positive for vascular markers, such as factor VIII-related antigen, CD31, and CD34. Hepatic EHE can have a varied clinical course; treatment includes liver transplantation, liver resection, chemotherapy, and radiation therapy. CASE SUMMARY: A 46-year-old woman with abdominal discomfort and elevated serum carcinoembryonic antigen was found to have multiple low-density lesions in the liver and lung on computed tomography (CT) evaluation. An ultrasound-guided fine needle aspiration biopsy revealed a fibrous stroma with dendritic cells, containing intracellular vacuoles. Immunohistochemical staining found that the tumor cells were positive for CD34, CD31, and factor VIII-related antigen. The patient received four courses of combined chemotherapy and was followed-up for 13 years, at which time the patient was in stable condition without disease progression and a confined neoplasm, as evidenced by CT scans. CONCLUSION: The histology and immunohistochemical characteristics of hepatic EHE are well described. Chemotherapy may be effective in patients with extrahepatic lesions. Baishideng Publishing Group Inc 2022-06-26 2022-06-26 /pmc/articles/PMC9254202/ /pubmed/35949854 http://dx.doi.org/10.12998/wjcc.v10.i18.6119 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Case Report Mo, Wei-Fang Tong, Yu-Ling Hepatic epithelioid hemangioendothelioma after thirteen years’ follow-up: A case report and review of literature |
title | Hepatic epithelioid hemangioendothelioma after thirteen years’ follow-up: A case report and review of literature |
title_full | Hepatic epithelioid hemangioendothelioma after thirteen years’ follow-up: A case report and review of literature |
title_fullStr | Hepatic epithelioid hemangioendothelioma after thirteen years’ follow-up: A case report and review of literature |
title_full_unstemmed | Hepatic epithelioid hemangioendothelioma after thirteen years’ follow-up: A case report and review of literature |
title_short | Hepatic epithelioid hemangioendothelioma after thirteen years’ follow-up: A case report and review of literature |
title_sort | hepatic epithelioid hemangioendothelioma after thirteen years’ follow-up: a case report and review of literature |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254202/ https://www.ncbi.nlm.nih.gov/pubmed/35949854 http://dx.doi.org/10.12998/wjcc.v10.i18.6119 |
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