Ultrasound-directed enzyme-prodrug therapy (UDEPT) using self-immolative doxorubicin derivatives

Background: Enzyme-activatable prodrugs are extensively employed in oncology and beyond. Because enzyme concentrations and their (sub)cellular compartmentalization are highly heterogeneous in different tumor types and patients, we propose ultrasound-directed enzyme-prodrug therapy (UDEPT) as a means...

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Detalles Bibliográficos
Autores principales: Roemhild, Karolin, Besse, Helena C., Wang, Bi, Peña, Quim, Sun, Qingxue, Omata, Daiki, Ozbakir, Burcin, Bos, Clemens, Scheeren, Hans W., Storm, Gert, Metselaar, Josbert M., Yu, Haijun, Knüchel-Clarke, Ruth, Kiessling, Fabian, Moonen, Chrit T.W., Deckers, Roel, Shi, Yang, Lammers, Twan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254251/
https://www.ncbi.nlm.nih.gov/pubmed/35832083
http://dx.doi.org/10.7150/thno.69168

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