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Personalized-Inherent Variability in a Time-Dependent Immune Response: A Look into the Fifth Dimension in Biology

INTRODUCTION: Individualized response to the immune triggers influences the course of immune-mediated diseases and the response to immunotherapies. Both inter- and intra-subject variations occur in time-dependent dynamics of biological systems. The present study aimed to establish a model for inhere...

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Autores principales: Rotnemer-Golinkin, Dory, Ilan, Yaron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254286/
https://www.ncbi.nlm.nih.gov/pubmed/35537442
http://dx.doi.org/10.1159/000524747
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author Rotnemer-Golinkin, Dory
Ilan, Yaron
author_facet Rotnemer-Golinkin, Dory
Ilan, Yaron
author_sort Rotnemer-Golinkin, Dory
collection PubMed
description INTRODUCTION: Individualized response to the immune triggers influences the course of immune-mediated diseases and the response to immunotherapies. Both inter- and intra-subject variations occur in time-dependent dynamics of biological systems. The present study aimed to establish a model for inherent personalized-time-dependent variability in response to immune triggers. METHODS: Male C57BL/6 mice were administered concanavalin A (ConA) and followed every 2 h for 10 h and at 24 h for serum alanine aminotransferase (ALT) levels. RESULTS: A marked intragroup variability was noted for both the timing of the effect of ConA, the magnitude of the increase in ALT levels, and the time to peak. While in some mice, a peak level was achieved, whereas a continuous increase in liver damage was noted in others. Four mice died at different time points during the study irrespective of their liver damage, further supporting the individualized-based response to the trigger. CONCLUSIONS: This feasibility study established a model for determining the personalized-inherent variability in a time-dependent response to the immune triggers. These results highlight the importance of considering both the time and the wide range of individualized variability in immune responses while designing personalized-based immunotherapies.
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spelling pubmed-92542862022-09-23 Personalized-Inherent Variability in a Time-Dependent Immune Response: A Look into the Fifth Dimension in Biology Rotnemer-Golinkin, Dory Ilan, Yaron Pharmacology Research Article INTRODUCTION: Individualized response to the immune triggers influences the course of immune-mediated diseases and the response to immunotherapies. Both inter- and intra-subject variations occur in time-dependent dynamics of biological systems. The present study aimed to establish a model for inherent personalized-time-dependent variability in response to immune triggers. METHODS: Male C57BL/6 mice were administered concanavalin A (ConA) and followed every 2 h for 10 h and at 24 h for serum alanine aminotransferase (ALT) levels. RESULTS: A marked intragroup variability was noted for both the timing of the effect of ConA, the magnitude of the increase in ALT levels, and the time to peak. While in some mice, a peak level was achieved, whereas a continuous increase in liver damage was noted in others. Four mice died at different time points during the study irrespective of their liver damage, further supporting the individualized-based response to the trigger. CONCLUSIONS: This feasibility study established a model for determining the personalized-inherent variability in a time-dependent response to the immune triggers. These results highlight the importance of considering both the time and the wide range of individualized variability in immune responses while designing personalized-based immunotherapies. S. Karger AG 2022-05-10 /pmc/articles/PMC9254286/ /pubmed/35537442 http://dx.doi.org/10.1159/000524747 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
spellingShingle Research Article
Rotnemer-Golinkin, Dory
Ilan, Yaron
Personalized-Inherent Variability in a Time-Dependent Immune Response: A Look into the Fifth Dimension in Biology
title Personalized-Inherent Variability in a Time-Dependent Immune Response: A Look into the Fifth Dimension in Biology
title_full Personalized-Inherent Variability in a Time-Dependent Immune Response: A Look into the Fifth Dimension in Biology
title_fullStr Personalized-Inherent Variability in a Time-Dependent Immune Response: A Look into the Fifth Dimension in Biology
title_full_unstemmed Personalized-Inherent Variability in a Time-Dependent Immune Response: A Look into the Fifth Dimension in Biology
title_short Personalized-Inherent Variability in a Time-Dependent Immune Response: A Look into the Fifth Dimension in Biology
title_sort personalized-inherent variability in a time-dependent immune response: a look into the fifth dimension in biology
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254286/
https://www.ncbi.nlm.nih.gov/pubmed/35537442
http://dx.doi.org/10.1159/000524747
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