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Usefulness of thyroid function assessment in infants born to mothers with thyroid dysfunction during pregnancy

INTRODUCTION: Maternal thyroid disease is considered as a risk factor for abnormal thyroid function at birth, as well as for long-term morbidity in offspring. The potential harmful effects on the neonate had led to the clinical practice of thyroid function assessment in infants born to mothers with...

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Autores principales: Ben-Zeev, Zohar Steinberg, Peniakov, Marina, Felszer, Clari, Weiner, Scott A, Lahad, Avishay, Almashanu, Shlomo, Tenenbaum Rakover, Yardena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254317/
https://www.ncbi.nlm.nih.gov/pubmed/35613337
http://dx.doi.org/10.1530/ETJ-22-0055
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author Ben-Zeev, Zohar Steinberg
Peniakov, Marina
Felszer, Clari
Weiner, Scott A
Lahad, Avishay
Almashanu, Shlomo
Tenenbaum Rakover, Yardena
author_facet Ben-Zeev, Zohar Steinberg
Peniakov, Marina
Felszer, Clari
Weiner, Scott A
Lahad, Avishay
Almashanu, Shlomo
Tenenbaum Rakover, Yardena
author_sort Ben-Zeev, Zohar Steinberg
collection PubMed
description INTRODUCTION: Maternal thyroid disease is considered as a risk factor for abnormal thyroid function at birth, as well as for long-term morbidity in offspring. The potential harmful effects on the neonate had led to the clinical practice of thyroid function assessment in infants born to mothers with thyroid disease during pregnancy. In this study, we evaluated the usefulness of routine thyroid function tests for every newborn of a mother with thyroid dysfunction. METHODS: Data were collected retrospectively from the medical files of mothers diagnosed with thyroid disease and their infants (496 mother–neonate pairs). All mothers with diagnosed thyroid disease who gave birth in the years 2016–2019 at our medical center were included. RESULTS: Hypothyroidism was the most common maternal diagnosis (91.4%), among which 48.7% had Hashimoto’s thyroiditis. Hyperthyroidism was diagnosed in 8.6% of the cohort – 71.6% of them with Graves’ disease. None of the newborns was diagnosed with congenital hypothyroidism in the screening program. Thyroid-stimulating hormone was >10 mIU/L in 14.6% and >20 mUI/L in 2.2%; all had free thyroxine within normal range. Serum thyroid function test identified four infants with thyroid disease; two had congenital hypothyroidism not related to maternal thyroid disease, one had transient familial congenital hypothyroidism and one had neonatal Graves’ disease. CONCLUSIONS: Thyroid function testing for all newborns of mothers with thyroid dysfunction seems redundant. However, in cases of congenital hypothyroidism in siblings, thyroid function test, in addition to newborn thyroid screening, is recommended, and more careful follow-up is indicated. In maternal Graves’ disease, thyroid function test on days 2–3 of life is recommended.
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spelling pubmed-92543172022-07-05 Usefulness of thyroid function assessment in infants born to mothers with thyroid dysfunction during pregnancy Ben-Zeev, Zohar Steinberg Peniakov, Marina Felszer, Clari Weiner, Scott A Lahad, Avishay Almashanu, Shlomo Tenenbaum Rakover, Yardena Eur Thyroid J Research INTRODUCTION: Maternal thyroid disease is considered as a risk factor for abnormal thyroid function at birth, as well as for long-term morbidity in offspring. The potential harmful effects on the neonate had led to the clinical practice of thyroid function assessment in infants born to mothers with thyroid disease during pregnancy. In this study, we evaluated the usefulness of routine thyroid function tests for every newborn of a mother with thyroid dysfunction. METHODS: Data were collected retrospectively from the medical files of mothers diagnosed with thyroid disease and their infants (496 mother–neonate pairs). All mothers with diagnosed thyroid disease who gave birth in the years 2016–2019 at our medical center were included. RESULTS: Hypothyroidism was the most common maternal diagnosis (91.4%), among which 48.7% had Hashimoto’s thyroiditis. Hyperthyroidism was diagnosed in 8.6% of the cohort – 71.6% of them with Graves’ disease. None of the newborns was diagnosed with congenital hypothyroidism in the screening program. Thyroid-stimulating hormone was >10 mIU/L in 14.6% and >20 mUI/L in 2.2%; all had free thyroxine within normal range. Serum thyroid function test identified four infants with thyroid disease; two had congenital hypothyroidism not related to maternal thyroid disease, one had transient familial congenital hypothyroidism and one had neonatal Graves’ disease. CONCLUSIONS: Thyroid function testing for all newborns of mothers with thyroid dysfunction seems redundant. However, in cases of congenital hypothyroidism in siblings, thyroid function test, in addition to newborn thyroid screening, is recommended, and more careful follow-up is indicated. In maternal Graves’ disease, thyroid function test on days 2–3 of life is recommended. Bioscientifica Ltd 2022-05-25 /pmc/articles/PMC9254317/ /pubmed/35613337 http://dx.doi.org/10.1530/ETJ-22-0055 Text en © The authors https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Research
Ben-Zeev, Zohar Steinberg
Peniakov, Marina
Felszer, Clari
Weiner, Scott A
Lahad, Avishay
Almashanu, Shlomo
Tenenbaum Rakover, Yardena
Usefulness of thyroid function assessment in infants born to mothers with thyroid dysfunction during pregnancy
title Usefulness of thyroid function assessment in infants born to mothers with thyroid dysfunction during pregnancy
title_full Usefulness of thyroid function assessment in infants born to mothers with thyroid dysfunction during pregnancy
title_fullStr Usefulness of thyroid function assessment in infants born to mothers with thyroid dysfunction during pregnancy
title_full_unstemmed Usefulness of thyroid function assessment in infants born to mothers with thyroid dysfunction during pregnancy
title_short Usefulness of thyroid function assessment in infants born to mothers with thyroid dysfunction during pregnancy
title_sort usefulness of thyroid function assessment in infants born to mothers with thyroid dysfunction during pregnancy
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254317/
https://www.ncbi.nlm.nih.gov/pubmed/35613337
http://dx.doi.org/10.1530/ETJ-22-0055
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