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Systemic lymphoma masquerading as Vogt-Koyanagi-Harada syndrome: Report of a case with multimodal imaging and histopathology
PURPOSE: To report a case of systemic diffuse large B cell lymphoma presenting with ocular manifestations and neurologic findings resembling Vogt-Koyanagi-Harada syndrome. OBSERVATIONS: A 51-year-old Caucasian man presented with headache, ear pain, and blurry vision in both eyes. He was found to hav...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254356/ https://www.ncbi.nlm.nih.gov/pubmed/35800404 http://dx.doi.org/10.1016/j.ajoc.2022.101643 |
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author | Moussa, Kareem Begaj, Tedi Ma, Kevin Barrantes, Paula Cortes Eliott, Dean Sobrin, Lucia |
author_facet | Moussa, Kareem Begaj, Tedi Ma, Kevin Barrantes, Paula Cortes Eliott, Dean Sobrin, Lucia |
author_sort | Moussa, Kareem |
collection | PubMed |
description | PURPOSE: To report a case of systemic diffuse large B cell lymphoma presenting with ocular manifestations and neurologic findings resembling Vogt-Koyanagi-Harada syndrome. OBSERVATIONS: A 51-year-old Caucasian man presented with headache, ear pain, and blurry vision in both eyes. He was found to have bilateral exudative retinal detachments. After a short period of initial improvement with high dose systemic corticosteroid, his condition significantly worsened. An extensive work-up, including a kidney biopsy, led to a diagnosis of systemic diffuse large B cell lymphoma. He had excellent recovery following treatment with appropriate chemotherapy. CONCLUSIONS AND IMPORTANCE: Systemic malignancy may present with ocular manifestations and may masquerade as another diagnosis. An unexpected clinical course may suggest an alternative diagnosis. A broad systemic work-up including an evaluation for malignancy should be considered for patients presenting with unexplained exam or systemic findings. |
format | Online Article Text |
id | pubmed-9254356 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-92543562022-07-06 Systemic lymphoma masquerading as Vogt-Koyanagi-Harada syndrome: Report of a case with multimodal imaging and histopathology Moussa, Kareem Begaj, Tedi Ma, Kevin Barrantes, Paula Cortes Eliott, Dean Sobrin, Lucia Am J Ophthalmol Case Rep Case Report PURPOSE: To report a case of systemic diffuse large B cell lymphoma presenting with ocular manifestations and neurologic findings resembling Vogt-Koyanagi-Harada syndrome. OBSERVATIONS: A 51-year-old Caucasian man presented with headache, ear pain, and blurry vision in both eyes. He was found to have bilateral exudative retinal detachments. After a short period of initial improvement with high dose systemic corticosteroid, his condition significantly worsened. An extensive work-up, including a kidney biopsy, led to a diagnosis of systemic diffuse large B cell lymphoma. He had excellent recovery following treatment with appropriate chemotherapy. CONCLUSIONS AND IMPORTANCE: Systemic malignancy may present with ocular manifestations and may masquerade as another diagnosis. An unexpected clinical course may suggest an alternative diagnosis. A broad systemic work-up including an evaluation for malignancy should be considered for patients presenting with unexplained exam or systemic findings. Elsevier 2022-06-28 /pmc/articles/PMC9254356/ /pubmed/35800404 http://dx.doi.org/10.1016/j.ajoc.2022.101643 Text en © 2022 Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Moussa, Kareem Begaj, Tedi Ma, Kevin Barrantes, Paula Cortes Eliott, Dean Sobrin, Lucia Systemic lymphoma masquerading as Vogt-Koyanagi-Harada syndrome: Report of a case with multimodal imaging and histopathology |
title | Systemic lymphoma masquerading as Vogt-Koyanagi-Harada syndrome: Report of a case with multimodal imaging and histopathology |
title_full | Systemic lymphoma masquerading as Vogt-Koyanagi-Harada syndrome: Report of a case with multimodal imaging and histopathology |
title_fullStr | Systemic lymphoma masquerading as Vogt-Koyanagi-Harada syndrome: Report of a case with multimodal imaging and histopathology |
title_full_unstemmed | Systemic lymphoma masquerading as Vogt-Koyanagi-Harada syndrome: Report of a case with multimodal imaging and histopathology |
title_short | Systemic lymphoma masquerading as Vogt-Koyanagi-Harada syndrome: Report of a case with multimodal imaging and histopathology |
title_sort | systemic lymphoma masquerading as vogt-koyanagi-harada syndrome: report of a case with multimodal imaging and histopathology |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254356/ https://www.ncbi.nlm.nih.gov/pubmed/35800404 http://dx.doi.org/10.1016/j.ajoc.2022.101643 |
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