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Systemic lymphoma masquerading as Vogt-Koyanagi-Harada syndrome: Report of a case with multimodal imaging and histopathology

PURPOSE: To report a case of systemic diffuse large B cell lymphoma presenting with ocular manifestations and neurologic findings resembling Vogt-Koyanagi-Harada syndrome. OBSERVATIONS: A 51-year-old Caucasian man presented with headache, ear pain, and blurry vision in both eyes. He was found to hav...

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Autores principales: Moussa, Kareem, Begaj, Tedi, Ma, Kevin, Barrantes, Paula Cortes, Eliott, Dean, Sobrin, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254356/
https://www.ncbi.nlm.nih.gov/pubmed/35800404
http://dx.doi.org/10.1016/j.ajoc.2022.101643
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author Moussa, Kareem
Begaj, Tedi
Ma, Kevin
Barrantes, Paula Cortes
Eliott, Dean
Sobrin, Lucia
author_facet Moussa, Kareem
Begaj, Tedi
Ma, Kevin
Barrantes, Paula Cortes
Eliott, Dean
Sobrin, Lucia
author_sort Moussa, Kareem
collection PubMed
description PURPOSE: To report a case of systemic diffuse large B cell lymphoma presenting with ocular manifestations and neurologic findings resembling Vogt-Koyanagi-Harada syndrome. OBSERVATIONS: A 51-year-old Caucasian man presented with headache, ear pain, and blurry vision in both eyes. He was found to have bilateral exudative retinal detachments. After a short period of initial improvement with high dose systemic corticosteroid, his condition significantly worsened. An extensive work-up, including a kidney biopsy, led to a diagnosis of systemic diffuse large B cell lymphoma. He had excellent recovery following treatment with appropriate chemotherapy. CONCLUSIONS AND IMPORTANCE: Systemic malignancy may present with ocular manifestations and may masquerade as another diagnosis. An unexpected clinical course may suggest an alternative diagnosis. A broad systemic work-up including an evaluation for malignancy should be considered for patients presenting with unexplained exam or systemic findings.
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spelling pubmed-92543562022-07-06 Systemic lymphoma masquerading as Vogt-Koyanagi-Harada syndrome: Report of a case with multimodal imaging and histopathology Moussa, Kareem Begaj, Tedi Ma, Kevin Barrantes, Paula Cortes Eliott, Dean Sobrin, Lucia Am J Ophthalmol Case Rep Case Report PURPOSE: To report a case of systemic diffuse large B cell lymphoma presenting with ocular manifestations and neurologic findings resembling Vogt-Koyanagi-Harada syndrome. OBSERVATIONS: A 51-year-old Caucasian man presented with headache, ear pain, and blurry vision in both eyes. He was found to have bilateral exudative retinal detachments. After a short period of initial improvement with high dose systemic corticosteroid, his condition significantly worsened. An extensive work-up, including a kidney biopsy, led to a diagnosis of systemic diffuse large B cell lymphoma. He had excellent recovery following treatment with appropriate chemotherapy. CONCLUSIONS AND IMPORTANCE: Systemic malignancy may present with ocular manifestations and may masquerade as another diagnosis. An unexpected clinical course may suggest an alternative diagnosis. A broad systemic work-up including an evaluation for malignancy should be considered for patients presenting with unexplained exam or systemic findings. Elsevier 2022-06-28 /pmc/articles/PMC9254356/ /pubmed/35800404 http://dx.doi.org/10.1016/j.ajoc.2022.101643 Text en © 2022 Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Moussa, Kareem
Begaj, Tedi
Ma, Kevin
Barrantes, Paula Cortes
Eliott, Dean
Sobrin, Lucia
Systemic lymphoma masquerading as Vogt-Koyanagi-Harada syndrome: Report of a case with multimodal imaging and histopathology
title Systemic lymphoma masquerading as Vogt-Koyanagi-Harada syndrome: Report of a case with multimodal imaging and histopathology
title_full Systemic lymphoma masquerading as Vogt-Koyanagi-Harada syndrome: Report of a case with multimodal imaging and histopathology
title_fullStr Systemic lymphoma masquerading as Vogt-Koyanagi-Harada syndrome: Report of a case with multimodal imaging and histopathology
title_full_unstemmed Systemic lymphoma masquerading as Vogt-Koyanagi-Harada syndrome: Report of a case with multimodal imaging and histopathology
title_short Systemic lymphoma masquerading as Vogt-Koyanagi-Harada syndrome: Report of a case with multimodal imaging and histopathology
title_sort systemic lymphoma masquerading as vogt-koyanagi-harada syndrome: report of a case with multimodal imaging and histopathology
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254356/
https://www.ncbi.nlm.nih.gov/pubmed/35800404
http://dx.doi.org/10.1016/j.ajoc.2022.101643
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