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ETV5 overexpression promotes progression of esophageal squamous cell carcinoma by upregulating SKA1 and TRPV2
Esophageal squamous cell carcinoma (ESCC) is notorious for the rapid progression especially early tumor metastasis due to the unclear mechanism. Recently, ETV5 attracts much attention for its potential role as an oncogenic transcription factor involved in multiple cancers. However, no one reported t...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254378/ https://www.ncbi.nlm.nih.gov/pubmed/35813298 http://dx.doi.org/10.7150/ijms.71892 |
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author | Sun, Ming-Chuang Fang, Kang Li, Zhao-Xing Chu, Yuan Xu, Ai-Ping Zhao, Zi-Ying Leng, Zhu-Yun Zhang, Yun-Wei Zhang, Ze-Hua Zhang, Li Chen, Tao Xu, Mei-Dong |
author_facet | Sun, Ming-Chuang Fang, Kang Li, Zhao-Xing Chu, Yuan Xu, Ai-Ping Zhao, Zi-Ying Leng, Zhu-Yun Zhang, Yun-Wei Zhang, Ze-Hua Zhang, Li Chen, Tao Xu, Mei-Dong |
author_sort | Sun, Ming-Chuang |
collection | PubMed |
description | Esophageal squamous cell carcinoma (ESCC) is notorious for the rapid progression especially early tumor metastasis due to the unclear mechanism. Recently, ETV5 attracts much attention for its potential role as an oncogenic transcription factor involved in multiple cancers. However, no one reported the mechanism behind the association between ETV5 expression and esophageal squamous cell carcinoma progression. In this study, we found that ETV5 was upregulated in ESCC both from online database and our ESCC tissues and ETV5 was associated with tumor staging and prognosis. Knockdown of ETV5 or its downstream genes SKA1 and TRPV2 significantly suppress ESCC cells migration and invasion, respectively. Additionally, in vivo study showed knockdown of ETV5 inhibited tumor metastasis. Further experiments unveiled ETV5 could transcriptionally upregulate the expression of SKA1 and TRPV2 and further activate MMPs in ESCC progression. In conclusion, ETV5 was associated with ESCC tumor staging and ESCC prognosis clinically. ETV5 promoted metastasis of ESCC by activating MMPs through augmenting the transcription of SKA1 and TRPV2. ETV5 was likely to be a novel oncogene and therapeutic target in ESCC. |
format | Online Article Text |
id | pubmed-9254378 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-92543782022-07-08 ETV5 overexpression promotes progression of esophageal squamous cell carcinoma by upregulating SKA1 and TRPV2 Sun, Ming-Chuang Fang, Kang Li, Zhao-Xing Chu, Yuan Xu, Ai-Ping Zhao, Zi-Ying Leng, Zhu-Yun Zhang, Yun-Wei Zhang, Ze-Hua Zhang, Li Chen, Tao Xu, Mei-Dong Int J Med Sci Research Paper Esophageal squamous cell carcinoma (ESCC) is notorious for the rapid progression especially early tumor metastasis due to the unclear mechanism. Recently, ETV5 attracts much attention for its potential role as an oncogenic transcription factor involved in multiple cancers. However, no one reported the mechanism behind the association between ETV5 expression and esophageal squamous cell carcinoma progression. In this study, we found that ETV5 was upregulated in ESCC both from online database and our ESCC tissues and ETV5 was associated with tumor staging and prognosis. Knockdown of ETV5 or its downstream genes SKA1 and TRPV2 significantly suppress ESCC cells migration and invasion, respectively. Additionally, in vivo study showed knockdown of ETV5 inhibited tumor metastasis. Further experiments unveiled ETV5 could transcriptionally upregulate the expression of SKA1 and TRPV2 and further activate MMPs in ESCC progression. In conclusion, ETV5 was associated with ESCC tumor staging and ESCC prognosis clinically. ETV5 promoted metastasis of ESCC by activating MMPs through augmenting the transcription of SKA1 and TRPV2. ETV5 was likely to be a novel oncogene and therapeutic target in ESCC. Ivyspring International Publisher 2022-06-21 /pmc/articles/PMC9254378/ /pubmed/35813298 http://dx.doi.org/10.7150/ijms.71892 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Sun, Ming-Chuang Fang, Kang Li, Zhao-Xing Chu, Yuan Xu, Ai-Ping Zhao, Zi-Ying Leng, Zhu-Yun Zhang, Yun-Wei Zhang, Ze-Hua Zhang, Li Chen, Tao Xu, Mei-Dong ETV5 overexpression promotes progression of esophageal squamous cell carcinoma by upregulating SKA1 and TRPV2 |
title | ETV5 overexpression promotes progression of esophageal squamous cell carcinoma by upregulating SKA1 and TRPV2 |
title_full | ETV5 overexpression promotes progression of esophageal squamous cell carcinoma by upregulating SKA1 and TRPV2 |
title_fullStr | ETV5 overexpression promotes progression of esophageal squamous cell carcinoma by upregulating SKA1 and TRPV2 |
title_full_unstemmed | ETV5 overexpression promotes progression of esophageal squamous cell carcinoma by upregulating SKA1 and TRPV2 |
title_short | ETV5 overexpression promotes progression of esophageal squamous cell carcinoma by upregulating SKA1 and TRPV2 |
title_sort | etv5 overexpression promotes progression of esophageal squamous cell carcinoma by upregulating ska1 and trpv2 |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254378/ https://www.ncbi.nlm.nih.gov/pubmed/35813298 http://dx.doi.org/10.7150/ijms.71892 |
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