Preconception vitamin D intake and obstetric outcomes in women using assisted reproductive technology: the Japan Environment and Children’s Study

BACKGROUND: In reproductive medicine, vitamin D (VitD) is of particular interest because its deficiency has been linked to various infertility issues. Thus, preconception care, including appropriate VitD supplementation, is essential, especially in women using assisted reproductive technology (ART)....

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Autores principales: Kyozuka, Hyo, Murata, Tsuyoshi, Fukuda, Toma, Imaizumi, Karin, Yamaguchi, Akiko, Yasuda, Shun, Suzuki, Daisuke, Sato, Akiko, Ogata, Yuka, Hosoya, Mitsuaki, Yasumura, Seiji, Hashimoto, Koichi, Nishigori, Hidekazu, Fujimori, Keiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254408/
https://www.ncbi.nlm.nih.gov/pubmed/35790896
http://dx.doi.org/10.1186/s12884-022-04861-2
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author Kyozuka, Hyo
Murata, Tsuyoshi
Fukuda, Toma
Imaizumi, Karin
Yamaguchi, Akiko
Yasuda, Shun
Suzuki, Daisuke
Sato, Akiko
Ogata, Yuka
Hosoya, Mitsuaki
Yasumura, Seiji
Hashimoto, Koichi
Nishigori, Hidekazu
Fujimori, Keiya
author_facet Kyozuka, Hyo
Murata, Tsuyoshi
Fukuda, Toma
Imaizumi, Karin
Yamaguchi, Akiko
Yasuda, Shun
Suzuki, Daisuke
Sato, Akiko
Ogata, Yuka
Hosoya, Mitsuaki
Yasumura, Seiji
Hashimoto, Koichi
Nishigori, Hidekazu
Fujimori, Keiya
author_sort Kyozuka, Hyo
collection PubMed
description BACKGROUND: In reproductive medicine, vitamin D (VitD) is of particular interest because its deficiency has been linked to various infertility issues. Thus, preconception care, including appropriate VitD supplementation, is essential, especially in women using assisted reproductive technology (ART). Despite the therapeutic benefits of VitD, adverse events due to a high daily intake may influence obstetric outcomes. However, the effects of either low or high preconception VitD intake on obstetric outcomes, including the outcomes in women who used ART, remain unclear. Therefore, the aim of this study was to examine the association between pre-pregnancy daily VitD intake and obstetric outcomes in Japanese women, including those who conceived through ART. METHODS: Data were obtained from the Japan Environment and Children’s study database comprising 92,571 women recruited between January 2011 and March 2014 in Japan. Participants were categorized into five quintiles according to pre-pregnancy VitD intake (Q1 and Q5 had the lowest and highest VitD intake, respectively) and stratified according to the use of ART. Multiple logistic regression was performed to identify the effects of pre-pregnancy VitD intake on preterm birth (PTB), low-birth weight infant (LBW), and small for gestational age (SGA). RESULTS: Using Q3 (middle VitD intake) as a reference, our analysis revealed that Q5 (highest VitD intake) showed an increased risk of LBW < 1500 g (adjusted odds ratio [aOR]: 1.09, 95% confidence interval [CI]: 1.00–1.18) and SGA (aOR: 1.26, 95% CI: 1.14–1.39) among women who conceived without ART. Among women who conceived with ART, we found that Q5 (highest VitD intake) showed an increased risk of PTB at < 37 weeks (aOR: 2.05, 95% CI: 1.27–3.31). CONCLUSION: The present study revealed that higher VitD intake before pregnancy may affect perinatal outcomes, particularly in women using ART. Our findings may facilitate personalized preconceptional counseling regarding VitD intake based on the method of conception, especially among women using ART.
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spelling pubmed-92544082022-07-06 Preconception vitamin D intake and obstetric outcomes in women using assisted reproductive technology: the Japan Environment and Children’s Study Kyozuka, Hyo Murata, Tsuyoshi Fukuda, Toma Imaizumi, Karin Yamaguchi, Akiko Yasuda, Shun Suzuki, Daisuke Sato, Akiko Ogata, Yuka Hosoya, Mitsuaki Yasumura, Seiji Hashimoto, Koichi Nishigori, Hidekazu Fujimori, Keiya BMC Pregnancy Childbirth Research BACKGROUND: In reproductive medicine, vitamin D (VitD) is of particular interest because its deficiency has been linked to various infertility issues. Thus, preconception care, including appropriate VitD supplementation, is essential, especially in women using assisted reproductive technology (ART). Despite the therapeutic benefits of VitD, adverse events due to a high daily intake may influence obstetric outcomes. However, the effects of either low or high preconception VitD intake on obstetric outcomes, including the outcomes in women who used ART, remain unclear. Therefore, the aim of this study was to examine the association between pre-pregnancy daily VitD intake and obstetric outcomes in Japanese women, including those who conceived through ART. METHODS: Data were obtained from the Japan Environment and Children’s study database comprising 92,571 women recruited between January 2011 and March 2014 in Japan. Participants were categorized into five quintiles according to pre-pregnancy VitD intake (Q1 and Q5 had the lowest and highest VitD intake, respectively) and stratified according to the use of ART. Multiple logistic regression was performed to identify the effects of pre-pregnancy VitD intake on preterm birth (PTB), low-birth weight infant (LBW), and small for gestational age (SGA). RESULTS: Using Q3 (middle VitD intake) as a reference, our analysis revealed that Q5 (highest VitD intake) showed an increased risk of LBW < 1500 g (adjusted odds ratio [aOR]: 1.09, 95% confidence interval [CI]: 1.00–1.18) and SGA (aOR: 1.26, 95% CI: 1.14–1.39) among women who conceived without ART. Among women who conceived with ART, we found that Q5 (highest VitD intake) showed an increased risk of PTB at < 37 weeks (aOR: 2.05, 95% CI: 1.27–3.31). CONCLUSION: The present study revealed that higher VitD intake before pregnancy may affect perinatal outcomes, particularly in women using ART. Our findings may facilitate personalized preconceptional counseling regarding VitD intake based on the method of conception, especially among women using ART. BioMed Central 2022-07-05 /pmc/articles/PMC9254408/ /pubmed/35790896 http://dx.doi.org/10.1186/s12884-022-04861-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Kyozuka, Hyo
Murata, Tsuyoshi
Fukuda, Toma
Imaizumi, Karin
Yamaguchi, Akiko
Yasuda, Shun
Suzuki, Daisuke
Sato, Akiko
Ogata, Yuka
Hosoya, Mitsuaki
Yasumura, Seiji
Hashimoto, Koichi
Nishigori, Hidekazu
Fujimori, Keiya
Preconception vitamin D intake and obstetric outcomes in women using assisted reproductive technology: the Japan Environment and Children’s Study
title Preconception vitamin D intake and obstetric outcomes in women using assisted reproductive technology: the Japan Environment and Children’s Study
title_full Preconception vitamin D intake and obstetric outcomes in women using assisted reproductive technology: the Japan Environment and Children’s Study
title_fullStr Preconception vitamin D intake and obstetric outcomes in women using assisted reproductive technology: the Japan Environment and Children’s Study
title_full_unstemmed Preconception vitamin D intake and obstetric outcomes in women using assisted reproductive technology: the Japan Environment and Children’s Study
title_short Preconception vitamin D intake and obstetric outcomes in women using assisted reproductive technology: the Japan Environment and Children’s Study
title_sort preconception vitamin d intake and obstetric outcomes in women using assisted reproductive technology: the japan environment and children’s study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254408/
https://www.ncbi.nlm.nih.gov/pubmed/35790896
http://dx.doi.org/10.1186/s12884-022-04861-2
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