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Increased spine PIP3 is sequestered from dendritic shafts

Phosphatidylinositol 3,4,5-trisphosphate (PIP3) is a lipid second messenger that is crucial for the synaptic plasticity underlying learning and memory in pyramidal neurons in the brain. Our previous study uncovered PIP3 enrichment in the dendritic spines of hippocampal pyramidal neurons in the stati...

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Detalles Bibliográficos
Autores principales: Ueda, Yoshibumi, Sugimoto, Naotoshi, Ozawa, Takeaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254409/
https://www.ncbi.nlm.nih.gov/pubmed/35787719
http://dx.doi.org/10.1186/s13041-022-00944-5