New discovery of high-affinity SARS-CoV-2 spike S2 protein binding peptide selected by PhIP-Seq

• A peptide Spep-1 targeting S2 of SARS-CoV-2 spike protein was selected by PhIP-Seq. • Spep-1 showed nanomolar affinity and high specificity to spike protein. • S-1 based immunoassay can detect femtomolar spike antigen in spiked serum samples. • Spep-1 can be used in future on S2 recognition, virus...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Mengyuan, He, Shuizhen, Xiong, Hualong, Zhang, Dongxu, Wang, Shaojuan, Hou, Wangheng, Zhu, Xiaomei, Wang, Jin, Huang, Yang, Hong, Congming, Wu, Yubin, Qi, Ruoyao, Zhang, Tianying, Yuan, Quan, Li, Tingdong, Chen, Yixin, Zhang, Shiyin, Ge, Shengxiang, Zhang, Jun, Xia, Ningshao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wuhan Institute of Virology, Chinese Academy of Sciences 2022
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254439/
https://www.ncbi.nlm.nih.gov/pubmed/35803529
http://dx.doi.org/10.1016/j.virs.2022.07.001
Descripción
Sumario:• A peptide Spep-1 targeting S2 of SARS-CoV-2 spike protein was selected by PhIP-Seq. • Spep-1 showed nanomolar affinity and high specificity to spike protein. • S-1 based immunoassay can detect femtomolar spike antigen in spiked serum samples. • Spep-1 can be used in future on S2 recognition, virus tracing and drug delivery.

Ejemplares similares