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Influence of clinical factors on the protective or deleterious impact of genetic variants in orthodontically induced external root resorption: an observational study

BACKGROUND: Prediction of susceptibility to Orthodontically Induced External Apical Root Resorption (OIEARR) has been hampered by the complex architecture of this multifactorial phenotype. The aim of this study was to analyze the impact of the interaction of multiple variables in the susceptibility...

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Autores principales: Silva, Henriqueta Coimbra, Lavado, Nuno, Canova, Filomena, Lopez, Miguel Guevara, Regateiro, Fernando J., Pereira, Sónia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254450/
https://www.ncbi.nlm.nih.gov/pubmed/35787289
http://dx.doi.org/10.1186/s12903-022-02306-y
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author Silva, Henriqueta Coimbra
Lavado, Nuno
Canova, Filomena
Lopez, Miguel Guevara
Regateiro, Fernando J.
Pereira, Sónia A.
author_facet Silva, Henriqueta Coimbra
Lavado, Nuno
Canova, Filomena
Lopez, Miguel Guevara
Regateiro, Fernando J.
Pereira, Sónia A.
author_sort Silva, Henriqueta Coimbra
collection PubMed
description BACKGROUND: Prediction of susceptibility to Orthodontically Induced External Apical Root Resorption (OIEARR) has been hampered by the complex architecture of this multifactorial phenotype. The aim of this study was to analyze the impact of the interaction of multiple variables in the susceptibility to OIEARR. METHODS: The study evaluated 195 patients requiring orthodontic treatment. Nine clinical and treatment variables, single nucleotide polymorphisms (SNPs) from five genes and variables interactions were analyzed as risk factors for OIEARR using a multiple linear regression model. RESULTS: The model explained 29% of OIEARR variability (ANOVA: p < 0.01). Duration of treatment was the most important predictor and gender was the second, closely followed by premolar extraction. For genes encoding osteoprotegerin (OPG), the receptor activator of nuclear factor κ B (RANK) and the IL1 receptor antagonist (IL1RN), the effect of analyzed variants changed from protective to deleterious depending on the duration of treatment and the age of the patient. CONCLUSIONS: This work shows that in OIEARR the impact of genetic susceptibility factors is dynamic changing according to clinical variables.
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spelling pubmed-92544502022-07-06 Influence of clinical factors on the protective or deleterious impact of genetic variants in orthodontically induced external root resorption: an observational study Silva, Henriqueta Coimbra Lavado, Nuno Canova, Filomena Lopez, Miguel Guevara Regateiro, Fernando J. Pereira, Sónia A. BMC Oral Health Research BACKGROUND: Prediction of susceptibility to Orthodontically Induced External Apical Root Resorption (OIEARR) has been hampered by the complex architecture of this multifactorial phenotype. The aim of this study was to analyze the impact of the interaction of multiple variables in the susceptibility to OIEARR. METHODS: The study evaluated 195 patients requiring orthodontic treatment. Nine clinical and treatment variables, single nucleotide polymorphisms (SNPs) from five genes and variables interactions were analyzed as risk factors for OIEARR using a multiple linear regression model. RESULTS: The model explained 29% of OIEARR variability (ANOVA: p < 0.01). Duration of treatment was the most important predictor and gender was the second, closely followed by premolar extraction. For genes encoding osteoprotegerin (OPG), the receptor activator of nuclear factor κ B (RANK) and the IL1 receptor antagonist (IL1RN), the effect of analyzed variants changed from protective to deleterious depending on the duration of treatment and the age of the patient. CONCLUSIONS: This work shows that in OIEARR the impact of genetic susceptibility factors is dynamic changing according to clinical variables. BioMed Central 2022-07-04 /pmc/articles/PMC9254450/ /pubmed/35787289 http://dx.doi.org/10.1186/s12903-022-02306-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Silva, Henriqueta Coimbra
Lavado, Nuno
Canova, Filomena
Lopez, Miguel Guevara
Regateiro, Fernando J.
Pereira, Sónia A.
Influence of clinical factors on the protective or deleterious impact of genetic variants in orthodontically induced external root resorption: an observational study
title Influence of clinical factors on the protective or deleterious impact of genetic variants in orthodontically induced external root resorption: an observational study
title_full Influence of clinical factors on the protective or deleterious impact of genetic variants in orthodontically induced external root resorption: an observational study
title_fullStr Influence of clinical factors on the protective or deleterious impact of genetic variants in orthodontically induced external root resorption: an observational study
title_full_unstemmed Influence of clinical factors on the protective or deleterious impact of genetic variants in orthodontically induced external root resorption: an observational study
title_short Influence of clinical factors on the protective or deleterious impact of genetic variants in orthodontically induced external root resorption: an observational study
title_sort influence of clinical factors on the protective or deleterious impact of genetic variants in orthodontically induced external root resorption: an observational study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254450/
https://www.ncbi.nlm.nih.gov/pubmed/35787289
http://dx.doi.org/10.1186/s12903-022-02306-y
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