A validated LC-MS/MS method for determination of antiviral prodrug molnupiravir in human plasma and its application for a pharmacokinetic modeling study in healthy Egyptian volunteers

A fully validated, simple, rapid and reproducible liquid chromatography-tandem mass spectrometry method was developed to determine NHC (N-hydroxycytidine), the active metabolite of Molnupiravir (MOL) in human plasma; one of the limited treatment options for SARS-CoV-2 in plasma of healthy volunteers...

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Detalles Bibliográficos
Autores principales: Gouda, Amira S., Marzouk, Hoda M., Rezk, Mamdouh R., Salem, Ahmed M., Morsi, Mosaad I., Nouman, Eman G., Abdallah, Youmna M., Hassan, Ahmed Y., Abdel-Megied, Ahmed M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254459/
https://www.ncbi.nlm.nih.gov/pubmed/35810537
http://dx.doi.org/10.1016/j.jchromb.2022.123363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254459/
https://www.ncbi.nlm.nih.gov/pubmed/35810537
http://dx.doi.org/10.1016/j.jchromb.2022.123363

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