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PRELIMINARY DATA ON LIVER TRANSPLANTATION IN HYDATIDOSIS DISEASE

Hydatidosis is a rare and endemic parasitic disease in Brazil that causes the proliferation of cysts mainly in the liver, leading to many complications, such as compression of vessels and biliary ducts, liver failure, portal hypertension, and cirrhosis. The treatment of choice is the resection of th...

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Autores principales: de CASTRO, Alexia Rangel, HYPPOLITO, Elodie Bomfim, VALENÇA-JÚNIOR, José Telmo, COELHO, Gustavo Rego, GARCIA, José Huygens Parente
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Colégio Brasileiro de Cirurgia Digestiva 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254553/
https://www.ncbi.nlm.nih.gov/pubmed/35766612
http://dx.doi.org/10.1590/0102-672020210002e1667
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author de CASTRO, Alexia Rangel
HYPPOLITO, Elodie Bomfim
VALENÇA-JÚNIOR, José Telmo
COELHO, Gustavo Rego
GARCIA, José Huygens Parente
author_facet de CASTRO, Alexia Rangel
HYPPOLITO, Elodie Bomfim
VALENÇA-JÚNIOR, José Telmo
COELHO, Gustavo Rego
GARCIA, José Huygens Parente
author_sort de CASTRO, Alexia Rangel
collection PubMed
description Hydatidosis is a rare and endemic parasitic disease in Brazil that causes the proliferation of cysts mainly in the liver, leading to many complications, such as compression of vessels and biliary ducts, liver failure, portal hypertension, and cirrhosis. The treatment of choice is the resection of the lesions combined with albendazole therapy. This disease is a rare indication for liver transplantation, a feasible treatment option in more advanced stages. AIM: The purpose of this study was to describe two cases of patients from northern Brazil who underwent liver transplantation due to hepatic hydatidosis. METHODS: This is a retrospective study with data collected from medical records. RESULTS: Case 1: A 51-year-old female patient presented pain in the right hypochondriac, dyspepsia, consumptive syndrome, and obstructive jaundice, with a previous diagnosis of Caroli’s disease with no possibility of surgical resection and a MELD score of 24. She underwent liver transplantation, and the anatomopathological result demonstrated hydatidosis. Case 2: A 52-year-old female patient presented multiple episodes of cholangitis in 30 years, with three liver resections and clinical treatment with albendazole for hydatidosis. She underwent liver transplantation due to recurrent cholangitis with a MELD score of 20. Both patients underwent post-transplant clinical therapy with albendazole, had good outcomes, and remain in follow-up without complications after 5 and 96 months, respectively. CONCLUSION: The patients benefited from the procedure and have a good prognosis due to the absence of metastasis, early reintroduction of antiparasitic drugs, and continuous follow-up.
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spelling pubmed-92545532022-07-18 PRELIMINARY DATA ON LIVER TRANSPLANTATION IN HYDATIDOSIS DISEASE de CASTRO, Alexia Rangel HYPPOLITO, Elodie Bomfim VALENÇA-JÚNIOR, José Telmo COELHO, Gustavo Rego GARCIA, José Huygens Parente Arq Bras Cir Dig Original Article Hydatidosis is a rare and endemic parasitic disease in Brazil that causes the proliferation of cysts mainly in the liver, leading to many complications, such as compression of vessels and biliary ducts, liver failure, portal hypertension, and cirrhosis. The treatment of choice is the resection of the lesions combined with albendazole therapy. This disease is a rare indication for liver transplantation, a feasible treatment option in more advanced stages. AIM: The purpose of this study was to describe two cases of patients from northern Brazil who underwent liver transplantation due to hepatic hydatidosis. METHODS: This is a retrospective study with data collected from medical records. RESULTS: Case 1: A 51-year-old female patient presented pain in the right hypochondriac, dyspepsia, consumptive syndrome, and obstructive jaundice, with a previous diagnosis of Caroli’s disease with no possibility of surgical resection and a MELD score of 24. She underwent liver transplantation, and the anatomopathological result demonstrated hydatidosis. Case 2: A 52-year-old female patient presented multiple episodes of cholangitis in 30 years, with three liver resections and clinical treatment with albendazole for hydatidosis. She underwent liver transplantation due to recurrent cholangitis with a MELD score of 20. Both patients underwent post-transplant clinical therapy with albendazole, had good outcomes, and remain in follow-up without complications after 5 and 96 months, respectively. CONCLUSION: The patients benefited from the procedure and have a good prognosis due to the absence of metastasis, early reintroduction of antiparasitic drugs, and continuous follow-up. Colégio Brasileiro de Cirurgia Digestiva 2022-06-24 /pmc/articles/PMC9254553/ /pubmed/35766612 http://dx.doi.org/10.1590/0102-672020210002e1667 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Original Article
de CASTRO, Alexia Rangel
HYPPOLITO, Elodie Bomfim
VALENÇA-JÚNIOR, José Telmo
COELHO, Gustavo Rego
GARCIA, José Huygens Parente
PRELIMINARY DATA ON LIVER TRANSPLANTATION IN HYDATIDOSIS DISEASE
title PRELIMINARY DATA ON LIVER TRANSPLANTATION IN HYDATIDOSIS DISEASE
title_full PRELIMINARY DATA ON LIVER TRANSPLANTATION IN HYDATIDOSIS DISEASE
title_fullStr PRELIMINARY DATA ON LIVER TRANSPLANTATION IN HYDATIDOSIS DISEASE
title_full_unstemmed PRELIMINARY DATA ON LIVER TRANSPLANTATION IN HYDATIDOSIS DISEASE
title_short PRELIMINARY DATA ON LIVER TRANSPLANTATION IN HYDATIDOSIS DISEASE
title_sort preliminary data on liver transplantation in hydatidosis disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254553/
https://www.ncbi.nlm.nih.gov/pubmed/35766612
http://dx.doi.org/10.1590/0102-672020210002e1667
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