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Aortic Stiffness in L-NAME Treated C57Bl/6 Mice Displays a Shift From Early Endothelial Dysfunction to Late-Term Vascular Smooth Muscle Cell Dysfunction

Introduction and Aims: Endothelial dysfunction is recognized as a cardiovascular aging hallmark. Administration of nitric oxide synthase blocker N-Ω-Nitro-L-arginine methyl ester hydrochloride (L-NAME) constitutes a well-known small animal model of cardiovascular aging. Despite extensive phenotypic...

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Detalles Bibliográficos
Autores principales:	De Moudt, Sofie, Hendrickx, Jhana O., Neutel, Cédric, De Munck, Dorien, Leloup, Arthur, De Meyer, Guido R.Y., Martinet, Wim, Fransen, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254682/ https://www.ncbi.nlm.nih.gov/pubmed/35800344 http://dx.doi.org/10.3389/fphys.2022.874015

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