The role of trace N-Oxyl compounds as redox mediator in enhancing antiviral ribavirin elimination in UV/Chlorine process

Ribavirin (RBV) is an antiviral drug used for treating COVID-19 infection. Its release into natural waters would threaten the health of aquatic ecosystem. This study reports an effective approach to degrade RBV by the trace N-oxyl compounds (2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) and N-Hydroxy...

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Autores principales: Sun, Qiyuan, Yang, Jing, Fan, Yongjie, Cai, Kaicong, Lu, Zhilei, He, Zhenle, Xu, Zeping, Lai, Xingteng, Zheng, Yuyi, Liu, Changqing, Wang, Feifeng, Sun, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254691/
https://www.ncbi.nlm.nih.gov/pubmed/35812172
http://dx.doi.org/10.1016/j.apcatb.2022.121709
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author Sun, Qiyuan
Yang, Jing
Fan, Yongjie
Cai, Kaicong
Lu, Zhilei
He, Zhenle
Xu, Zeping
Lai, Xingteng
Zheng, Yuyi
Liu, Changqing
Wang, Feifeng
Sun, Zhe
author_facet Sun, Qiyuan
Yang, Jing
Fan, Yongjie
Cai, Kaicong
Lu, Zhilei
He, Zhenle
Xu, Zeping
Lai, Xingteng
Zheng, Yuyi
Liu, Changqing
Wang, Feifeng
Sun, Zhe
author_sort Sun, Qiyuan
collection PubMed
description Ribavirin (RBV) is an antiviral drug used for treating COVID-19 infection. Its release into natural waters would threaten the health of aquatic ecosystem. This study reports an effective approach to degrade RBV by the trace N-oxyl compounds (2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) and N-Hydroxyphthalimide (NHPI)) enhanced UV activated free chlorine (UV/Chlorine) process. The results indicated that TEMPO and NHPI at low concentrations (0.1 μM and 1 μM, respectively) could strongly enhance RBV degradation in both deionized water with different pHs and practical surface water. The enhancement was verified to be attributed to the transformation of TEMPO and NHPI into their reactive forms (i.e., TEMPO(+) and PINO), which generations deeply relied on radicals. The two N-oxyl compounds inhibit ClO• yield by hindering the reaction of free chlorine vs. HO• and Cl•. The analyses on acute toxicities of RBV degradation products indicate that UV/Chlorine/N-oxyl compounds process can detoxify RBV more efficiently than UV/Chlorine process.
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spelling pubmed-92546912022-07-05 The role of trace N-Oxyl compounds as redox mediator in enhancing antiviral ribavirin elimination in UV/Chlorine process Sun, Qiyuan Yang, Jing Fan, Yongjie Cai, Kaicong Lu, Zhilei He, Zhenle Xu, Zeping Lai, Xingteng Zheng, Yuyi Liu, Changqing Wang, Feifeng Sun, Zhe Appl Catal B Article Ribavirin (RBV) is an antiviral drug used for treating COVID-19 infection. Its release into natural waters would threaten the health of aquatic ecosystem. This study reports an effective approach to degrade RBV by the trace N-oxyl compounds (2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) and N-Hydroxyphthalimide (NHPI)) enhanced UV activated free chlorine (UV/Chlorine) process. The results indicated that TEMPO and NHPI at low concentrations (0.1 μM and 1 μM, respectively) could strongly enhance RBV degradation in both deionized water with different pHs and practical surface water. The enhancement was verified to be attributed to the transformation of TEMPO and NHPI into their reactive forms (i.e., TEMPO(+) and PINO), which generations deeply relied on radicals. The two N-oxyl compounds inhibit ClO• yield by hindering the reaction of free chlorine vs. HO• and Cl•. The analyses on acute toxicities of RBV degradation products indicate that UV/Chlorine/N-oxyl compounds process can detoxify RBV more efficiently than UV/Chlorine process. Elsevier B.V. 2022-11-15 2022-07-05 /pmc/articles/PMC9254691/ /pubmed/35812172 http://dx.doi.org/10.1016/j.apcatb.2022.121709 Text en © 2022 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Sun, Qiyuan
Yang, Jing
Fan, Yongjie
Cai, Kaicong
Lu, Zhilei
He, Zhenle
Xu, Zeping
Lai, Xingteng
Zheng, Yuyi
Liu, Changqing
Wang, Feifeng
Sun, Zhe
The role of trace N-Oxyl compounds as redox mediator in enhancing antiviral ribavirin elimination in UV/Chlorine process
title The role of trace N-Oxyl compounds as redox mediator in enhancing antiviral ribavirin elimination in UV/Chlorine process
title_full The role of trace N-Oxyl compounds as redox mediator in enhancing antiviral ribavirin elimination in UV/Chlorine process
title_fullStr The role of trace N-Oxyl compounds as redox mediator in enhancing antiviral ribavirin elimination in UV/Chlorine process
title_full_unstemmed The role of trace N-Oxyl compounds as redox mediator in enhancing antiviral ribavirin elimination in UV/Chlorine process
title_short The role of trace N-Oxyl compounds as redox mediator in enhancing antiviral ribavirin elimination in UV/Chlorine process
title_sort role of trace n-oxyl compounds as redox mediator in enhancing antiviral ribavirin elimination in uv/chlorine process
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254691/
https://www.ncbi.nlm.nih.gov/pubmed/35812172
http://dx.doi.org/10.1016/j.apcatb.2022.121709
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