Cargando…
Evaluation of the effect of intrauterine injection of platelet-rich plasma on the pregnancy rate of patients with a history of implantation failure in the in vitro fertilization cycle
OBJECTIVES: Implantation failure is a major problem in reproductive medicine, and despite the various methods described for treatment, there is little consensus on the most effective method. This study was conducted to investigate the effect of intrauterine injection of platelet-rich plasma (PRP) on...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254800/ https://www.ncbi.nlm.nih.gov/pubmed/35800474 http://dx.doi.org/10.4103/jfmpc.jfmpc_1817_21 |
_version_ | 1784740783349301248 |
---|---|
author | Ershadi, Sara Noori, Narjes Dashipoor, Alireza Ghasemi, Marzieh Shamsa, Nahid |
author_facet | Ershadi, Sara Noori, Narjes Dashipoor, Alireza Ghasemi, Marzieh Shamsa, Nahid |
author_sort | Ershadi, Sara |
collection | PubMed |
description | OBJECTIVES: Implantation failure is a major problem in reproductive medicine, and despite the various methods described for treatment, there is little consensus on the most effective method. This study was conducted to investigate the effect of intrauterine injection of platelet-rich plasma (PRP) on the pregnancy rate of patients with a history of implantation failure in the in vitro fertilization (IVF) cycle. STUDY DESIGN: In this study, women attending the infertility clinic of Ali ibn Abi Taleb Hospital, who had a history of implantation failure and were candidates for frozen embryo transfer (FET), were examined in Zahedan (Iran) in 2019. The patients were divided into two groups of PRP recipients and the control group. IVF was performed routinely, and in the PRP-receiving group, an intrauterine injection was given 48 h before embryo transfer (ET). The number of gestational sacs, the rate of implantation, the frequency of chemical and clinical pregnancies as well as the frequency of abortion were compared in the two groups. The collected data were analyzed by the SPSS software version 21 RESULTS: Ninety patients with a history of implantation failure participated in the study, and finally, the information of 85 patients was studied. The frequency of chemical pregnancy was 40% in the experimental group, 27% in the control group, and regarding clinical pregnancy, 33% in the experimental group and 24% in the control group, but there was no significant difference between the two groups. The rate of implantation, the mean thickness of the endometrium, and the frequency of abortion did not differ significantly between the two groups CONCLUSION: In patients with endometrial thickness greater than 8 mm with a history of recurrent implantation failure, intrauterine injection of PRP had no effect on the fertility outcome. |
format | Online Article Text |
id | pubmed-9254800 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-92548002022-07-06 Evaluation of the effect of intrauterine injection of platelet-rich plasma on the pregnancy rate of patients with a history of implantation failure in the in vitro fertilization cycle Ershadi, Sara Noori, Narjes Dashipoor, Alireza Ghasemi, Marzieh Shamsa, Nahid J Family Med Prim Care Original Article OBJECTIVES: Implantation failure is a major problem in reproductive medicine, and despite the various methods described for treatment, there is little consensus on the most effective method. This study was conducted to investigate the effect of intrauterine injection of platelet-rich plasma (PRP) on the pregnancy rate of patients with a history of implantation failure in the in vitro fertilization (IVF) cycle. STUDY DESIGN: In this study, women attending the infertility clinic of Ali ibn Abi Taleb Hospital, who had a history of implantation failure and were candidates for frozen embryo transfer (FET), were examined in Zahedan (Iran) in 2019. The patients were divided into two groups of PRP recipients and the control group. IVF was performed routinely, and in the PRP-receiving group, an intrauterine injection was given 48 h before embryo transfer (ET). The number of gestational sacs, the rate of implantation, the frequency of chemical and clinical pregnancies as well as the frequency of abortion were compared in the two groups. The collected data were analyzed by the SPSS software version 21 RESULTS: Ninety patients with a history of implantation failure participated in the study, and finally, the information of 85 patients was studied. The frequency of chemical pregnancy was 40% in the experimental group, 27% in the control group, and regarding clinical pregnancy, 33% in the experimental group and 24% in the control group, but there was no significant difference between the two groups. The rate of implantation, the mean thickness of the endometrium, and the frequency of abortion did not differ significantly between the two groups CONCLUSION: In patients with endometrial thickness greater than 8 mm with a history of recurrent implantation failure, intrauterine injection of PRP had no effect on the fertility outcome. Wolters Kluwer - Medknow 2022-05 2022-05-14 /pmc/articles/PMC9254800/ /pubmed/35800474 http://dx.doi.org/10.4103/jfmpc.jfmpc_1817_21 Text en Copyright: © 2022 Journal of Family Medicine and Primary Care https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Ershadi, Sara Noori, Narjes Dashipoor, Alireza Ghasemi, Marzieh Shamsa, Nahid Evaluation of the effect of intrauterine injection of platelet-rich plasma on the pregnancy rate of patients with a history of implantation failure in the in vitro fertilization cycle |
title | Evaluation of the effect of intrauterine injection of platelet-rich plasma on the pregnancy rate of patients with a history of implantation failure in the in vitro fertilization cycle |
title_full | Evaluation of the effect of intrauterine injection of platelet-rich plasma on the pregnancy rate of patients with a history of implantation failure in the in vitro fertilization cycle |
title_fullStr | Evaluation of the effect of intrauterine injection of platelet-rich plasma on the pregnancy rate of patients with a history of implantation failure in the in vitro fertilization cycle |
title_full_unstemmed | Evaluation of the effect of intrauterine injection of platelet-rich plasma on the pregnancy rate of patients with a history of implantation failure in the in vitro fertilization cycle |
title_short | Evaluation of the effect of intrauterine injection of platelet-rich plasma on the pregnancy rate of patients with a history of implantation failure in the in vitro fertilization cycle |
title_sort | evaluation of the effect of intrauterine injection of platelet-rich plasma on the pregnancy rate of patients with a history of implantation failure in the in vitro fertilization cycle |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254800/ https://www.ncbi.nlm.nih.gov/pubmed/35800474 http://dx.doi.org/10.4103/jfmpc.jfmpc_1817_21 |
work_keys_str_mv | AT ershadisara evaluationoftheeffectofintrauterineinjectionofplateletrichplasmaonthepregnancyrateofpatientswithahistoryofimplantationfailureintheinvitrofertilizationcycle AT noorinarjes evaluationoftheeffectofintrauterineinjectionofplateletrichplasmaonthepregnancyrateofpatientswithahistoryofimplantationfailureintheinvitrofertilizationcycle AT dashipooralireza evaluationoftheeffectofintrauterineinjectionofplateletrichplasmaonthepregnancyrateofpatientswithahistoryofimplantationfailureintheinvitrofertilizationcycle AT ghasemimarzieh evaluationoftheeffectofintrauterineinjectionofplateletrichplasmaonthepregnancyrateofpatientswithahistoryofimplantationfailureintheinvitrofertilizationcycle AT shamsanahid evaluationoftheeffectofintrauterineinjectionofplateletrichplasmaonthepregnancyrateofpatientswithahistoryofimplantationfailureintheinvitrofertilizationcycle |