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Oral nifedipine and parenteral isoxsuprine in arresting preterm labor: A comparative study

OBJECTIVE: To compare the efficacy of oral nifedipine and parenteral isoxsuprine in arresting preterm labor. Considering the paucity of studies comparing these two agents, a comparative analysis is obligatory. MATERIALS AND METHODS: Eighty antenatal women in the gestational age range of 28–37 weeks,...

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Autores principales: Ray, Namrata, Kshirsagar, Nitin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254824/
https://www.ncbi.nlm.nih.gov/pubmed/35800477
http://dx.doi.org/10.4103/jfmpc.jfmpc_1696_20
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author Ray, Namrata
Kshirsagar, Nitin
author_facet Ray, Namrata
Kshirsagar, Nitin
author_sort Ray, Namrata
collection PubMed
description OBJECTIVE: To compare the efficacy of oral nifedipine and parenteral isoxsuprine in arresting preterm labor. Considering the paucity of studies comparing these two agents, a comparative analysis is obligatory. MATERIALS AND METHODS: Eighty antenatal women in the gestational age range of 28–37 weeks, with regular uterine contractions, cervical dilatation ≤3 cm, and <50% cervical effacement, admitted with complaints of preterm labor pain were randomized to receive either 40 mg isoxsuprine or 20 mg nifedipine. Efficacy of the drugs was measured in terms of arrest of preterm labor, prolongation of pregnancy, and the days gained by infant before birth. RESULTS: Isoxsuprine showed increased lowering of systolic blood pressure (SBP), diastolic blood pressure (DBP), and slightly higher maternal pulse rate, but higher fetal pulse rate post-administration in comparison to nifedipine (P < 0.05). Isoxsuprine was significantly associated with more side effects. Pregnancy was more prolonged in the nifedipine group (25 days) than in the isoxsuprine group (19 days) (P < 0.05). The birth weight of neonates in group B was more than that of neonates in group A (P < 0.05). At 5 min after birth, none of the neonates in group B had an Appearance, Pulse, Grimace, Activity, and Respiration (APGAR) abnormal score <7, compared to neonates in group A. Majority of neonates in group A showed tachycardia and respiratory distress syndrome (RDS) (17.5% and 12.5%, respectively), compared to group B (12.5% and 7.5%, respectively). The overall success rate was better in group B (86.8%) compared to group A (80%). CONCLUSION: Nifedipine was slightly more effective in arresting preterm labor with fewer side effects, compared to isoxsuprine.
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spelling pubmed-92548242022-07-06 Oral nifedipine and parenteral isoxsuprine in arresting preterm labor: A comparative study Ray, Namrata Kshirsagar, Nitin J Family Med Prim Care Original Article OBJECTIVE: To compare the efficacy of oral nifedipine and parenteral isoxsuprine in arresting preterm labor. Considering the paucity of studies comparing these two agents, a comparative analysis is obligatory. MATERIALS AND METHODS: Eighty antenatal women in the gestational age range of 28–37 weeks, with regular uterine contractions, cervical dilatation ≤3 cm, and <50% cervical effacement, admitted with complaints of preterm labor pain were randomized to receive either 40 mg isoxsuprine or 20 mg nifedipine. Efficacy of the drugs was measured in terms of arrest of preterm labor, prolongation of pregnancy, and the days gained by infant before birth. RESULTS: Isoxsuprine showed increased lowering of systolic blood pressure (SBP), diastolic blood pressure (DBP), and slightly higher maternal pulse rate, but higher fetal pulse rate post-administration in comparison to nifedipine (P < 0.05). Isoxsuprine was significantly associated with more side effects. Pregnancy was more prolonged in the nifedipine group (25 days) than in the isoxsuprine group (19 days) (P < 0.05). The birth weight of neonates in group B was more than that of neonates in group A (P < 0.05). At 5 min after birth, none of the neonates in group B had an Appearance, Pulse, Grimace, Activity, and Respiration (APGAR) abnormal score <7, compared to neonates in group A. Majority of neonates in group A showed tachycardia and respiratory distress syndrome (RDS) (17.5% and 12.5%, respectively), compared to group B (12.5% and 7.5%, respectively). The overall success rate was better in group B (86.8%) compared to group A (80%). CONCLUSION: Nifedipine was slightly more effective in arresting preterm labor with fewer side effects, compared to isoxsuprine. Wolters Kluwer - Medknow 2022-05 2022-05-14 /pmc/articles/PMC9254824/ /pubmed/35800477 http://dx.doi.org/10.4103/jfmpc.jfmpc_1696_20 Text en Copyright: © 2022 Journal of Family Medicine and Primary Care https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Ray, Namrata
Kshirsagar, Nitin
Oral nifedipine and parenteral isoxsuprine in arresting preterm labor: A comparative study
title Oral nifedipine and parenteral isoxsuprine in arresting preterm labor: A comparative study
title_full Oral nifedipine and parenteral isoxsuprine in arresting preterm labor: A comparative study
title_fullStr Oral nifedipine and parenteral isoxsuprine in arresting preterm labor: A comparative study
title_full_unstemmed Oral nifedipine and parenteral isoxsuprine in arresting preterm labor: A comparative study
title_short Oral nifedipine and parenteral isoxsuprine in arresting preterm labor: A comparative study
title_sort oral nifedipine and parenteral isoxsuprine in arresting preterm labor: a comparative study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254824/
https://www.ncbi.nlm.nih.gov/pubmed/35800477
http://dx.doi.org/10.4103/jfmpc.jfmpc_1696_20
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