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Incorporation of a histone mutant with H3K56 site substitution perturbs the replication machinery in mouse embryonic stem cells

Sense mutations in several conserved modifiable sites of histone H3 have been found to be strongly correlated with multiple tissue-specific clinical cancers. These clinical site mutants acquire a distinctively new epigenetic role and mediate cancer evolution. In this study, we mimicked histone H3 at...

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Detalles Bibliográficos
Autores principales:	Kang, Xuan, Yang, Xiaomei, Guo, Xiaobo, Li, Yabin, Yang, Chenxin, Wei, Huimin, Chang, Jianfeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254884/ https://www.ncbi.nlm.nih.gov/pubmed/35259279 http://dx.doi.org/10.1093/jmcb/mjac014

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