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Oncolytic adenovirus promotes vascular normalization and nonclassical tertiary lymphoid structure formation through STING-mediated DC activation
Inducing a full antitumor immune response in the tumor microenvironment (TME) is essential for successful cancer immunotherapy. Here, we report that an oncolytic adenovirus carrying mIL-15 (Ad-IL15) can effectively induce antitumor immune response and inhibit tumor growth in a mouse model of cancer....
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255224/ https://www.ncbi.nlm.nih.gov/pubmed/35800155 http://dx.doi.org/10.1080/2162402X.2022.2093054 |
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author | He, Teng Hao, Zhixing Lin, Mingjie Xin, Zhongwei Chen, Yongyuan Ouyang, Wei Yang, Qi Chen, Xiaoke Zhou, Hui Zhang, Wanying Wu, Pin Xu, Feng |
author_facet | He, Teng Hao, Zhixing Lin, Mingjie Xin, Zhongwei Chen, Yongyuan Ouyang, Wei Yang, Qi Chen, Xiaoke Zhou, Hui Zhang, Wanying Wu, Pin Xu, Feng |
author_sort | He, Teng |
collection | PubMed |
description | Inducing a full antitumor immune response in the tumor microenvironment (TME) is essential for successful cancer immunotherapy. Here, we report that an oncolytic adenovirus carrying mIL-15 (Ad-IL15) can effectively induce antitumor immune response and inhibit tumor growth in a mouse model of cancer. We found that Ad-IL15 facilitated the activation and infiltration of immune cells, including dendritic cells (DCs), T cells and natural killer (NK) cells, in the TME. Unexpectedly, we observed that Ad-IL15 also induced vascular normalization and tertiary lymphoid structure formation in the TME. Moreover, we demonstrated these Ad-IL15-induced changes in the TME were depended on the Ad-IL15-induced activation of the STING-TBK1-IRF3 pathway in DCs. Taken together, our findings suggest that Ad-IL15 is a candidate for cancer immunotherapy that promotes immune cell activation and infiltration, tumor vascular normalization and tertiary lymphoid structure formation in the TME. |
format | Online Article Text |
id | pubmed-9255224 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-92552242022-07-06 Oncolytic adenovirus promotes vascular normalization and nonclassical tertiary lymphoid structure formation through STING-mediated DC activation He, Teng Hao, Zhixing Lin, Mingjie Xin, Zhongwei Chen, Yongyuan Ouyang, Wei Yang, Qi Chen, Xiaoke Zhou, Hui Zhang, Wanying Wu, Pin Xu, Feng Oncoimmunology Original Research Inducing a full antitumor immune response in the tumor microenvironment (TME) is essential for successful cancer immunotherapy. Here, we report that an oncolytic adenovirus carrying mIL-15 (Ad-IL15) can effectively induce antitumor immune response and inhibit tumor growth in a mouse model of cancer. We found that Ad-IL15 facilitated the activation and infiltration of immune cells, including dendritic cells (DCs), T cells and natural killer (NK) cells, in the TME. Unexpectedly, we observed that Ad-IL15 also induced vascular normalization and tertiary lymphoid structure formation in the TME. Moreover, we demonstrated these Ad-IL15-induced changes in the TME were depended on the Ad-IL15-induced activation of the STING-TBK1-IRF3 pathway in DCs. Taken together, our findings suggest that Ad-IL15 is a candidate for cancer immunotherapy that promotes immune cell activation and infiltration, tumor vascular normalization and tertiary lymphoid structure formation in the TME. Taylor & Francis 2022-07-01 /pmc/articles/PMC9255224/ /pubmed/35800155 http://dx.doi.org/10.1080/2162402X.2022.2093054 Text en © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research He, Teng Hao, Zhixing Lin, Mingjie Xin, Zhongwei Chen, Yongyuan Ouyang, Wei Yang, Qi Chen, Xiaoke Zhou, Hui Zhang, Wanying Wu, Pin Xu, Feng Oncolytic adenovirus promotes vascular normalization and nonclassical tertiary lymphoid structure formation through STING-mediated DC activation |
title | Oncolytic adenovirus promotes vascular normalization and nonclassical tertiary lymphoid structure formation through STING-mediated DC activation |
title_full | Oncolytic adenovirus promotes vascular normalization and nonclassical tertiary lymphoid structure formation through STING-mediated DC activation |
title_fullStr | Oncolytic adenovirus promotes vascular normalization and nonclassical tertiary lymphoid structure formation through STING-mediated DC activation |
title_full_unstemmed | Oncolytic adenovirus promotes vascular normalization and nonclassical tertiary lymphoid structure formation through STING-mediated DC activation |
title_short | Oncolytic adenovirus promotes vascular normalization and nonclassical tertiary lymphoid structure formation through STING-mediated DC activation |
title_sort | oncolytic adenovirus promotes vascular normalization and nonclassical tertiary lymphoid structure formation through sting-mediated dc activation |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255224/ https://www.ncbi.nlm.nih.gov/pubmed/35800155 http://dx.doi.org/10.1080/2162402X.2022.2093054 |
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