Cargando…

Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders

Neuropeptides, a diverse class of signaling molecules in the nervous system, modulate various biological effects including membrane excitability, synaptic transmission and synaptogenesis, gene expression, and glial cell architecture and function. To date, most of what is known about neuropeptide act...

Descripción completa

Detalles Bibliográficos
Autores principales: Casello, Sanne M., Flores, Rodolfo J., Yarur, Hector E., Wang, Huikun, Awanyai, Monique, Arenivar, Miguel A., Jaime-Lara, Rosario B., Bravo-Rivera, Hector, Tejeda, Hugo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255232/
https://www.ncbi.nlm.nih.gov/pubmed/35800635
http://dx.doi.org/10.3389/fncir.2022.796443
_version_ 1784740882364235776
author Casello, Sanne M.
Flores, Rodolfo J.
Yarur, Hector E.
Wang, Huikun
Awanyai, Monique
Arenivar, Miguel A.
Jaime-Lara, Rosario B.
Bravo-Rivera, Hector
Tejeda, Hugo A.
author_facet Casello, Sanne M.
Flores, Rodolfo J.
Yarur, Hector E.
Wang, Huikun
Awanyai, Monique
Arenivar, Miguel A.
Jaime-Lara, Rosario B.
Bravo-Rivera, Hector
Tejeda, Hugo A.
author_sort Casello, Sanne M.
collection PubMed
description Neuropeptides, a diverse class of signaling molecules in the nervous system, modulate various biological effects including membrane excitability, synaptic transmission and synaptogenesis, gene expression, and glial cell architecture and function. To date, most of what is known about neuropeptide action is limited to subcortical brain structures and tissue outside of the central nervous system. Thus, there is a knowledge gap in our understanding of neuropeptide function within cortical circuits. In this review, we provide a comprehensive overview of various families of neuropeptides and their cognate receptors that are expressed in the prefrontal cortex (PFC). Specifically, we highlight dynorphin, enkephalin, corticotropin-releasing factor, cholecystokinin, somatostatin, neuropeptide Y, and vasoactive intestinal peptide. Further, we review the implication of neuropeptide signaling in prefrontal cortical circuit function and use as potential therapeutic targets. Together, this review summarizes established knowledge and highlights unknowns of neuropeptide modulation of neural function underlying various biological effects while offering insights for future research. An increased emphasis in this area of study is necessary to elucidate basic principles of the diverse signaling molecules used in cortical circuits beyond fast excitatory and inhibitory transmitters as well as consider components of neuropeptide action in the PFC as a potential therapeutic target for neurological disorders. Therefore, this review not only sheds light on the importance of cortical neuropeptide studies, but also provides a comprehensive overview of neuropeptide action in the PFC to serve as a roadmap for future studies in this field.
format Online
Article
Text
id pubmed-9255232
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-92552322022-07-06 Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders Casello, Sanne M. Flores, Rodolfo J. Yarur, Hector E. Wang, Huikun Awanyai, Monique Arenivar, Miguel A. Jaime-Lara, Rosario B. Bravo-Rivera, Hector Tejeda, Hugo A. Front Neural Circuits Neural Circuits Neuropeptides, a diverse class of signaling molecules in the nervous system, modulate various biological effects including membrane excitability, synaptic transmission and synaptogenesis, gene expression, and glial cell architecture and function. To date, most of what is known about neuropeptide action is limited to subcortical brain structures and tissue outside of the central nervous system. Thus, there is a knowledge gap in our understanding of neuropeptide function within cortical circuits. In this review, we provide a comprehensive overview of various families of neuropeptides and their cognate receptors that are expressed in the prefrontal cortex (PFC). Specifically, we highlight dynorphin, enkephalin, corticotropin-releasing factor, cholecystokinin, somatostatin, neuropeptide Y, and vasoactive intestinal peptide. Further, we review the implication of neuropeptide signaling in prefrontal cortical circuit function and use as potential therapeutic targets. Together, this review summarizes established knowledge and highlights unknowns of neuropeptide modulation of neural function underlying various biological effects while offering insights for future research. An increased emphasis in this area of study is necessary to elucidate basic principles of the diverse signaling molecules used in cortical circuits beyond fast excitatory and inhibitory transmitters as well as consider components of neuropeptide action in the PFC as a potential therapeutic target for neurological disorders. Therefore, this review not only sheds light on the importance of cortical neuropeptide studies, but also provides a comprehensive overview of neuropeptide action in the PFC to serve as a roadmap for future studies in this field. Frontiers Media S.A. 2022-06-21 /pmc/articles/PMC9255232/ /pubmed/35800635 http://dx.doi.org/10.3389/fncir.2022.796443 Text en Copyright © 2022 Casello, Flores, Yarur, Wang, Awanyai, Arenivar, Jaime-Lara, Bravo-Rivera and Tejeda. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neural Circuits
Casello, Sanne M.
Flores, Rodolfo J.
Yarur, Hector E.
Wang, Huikun
Awanyai, Monique
Arenivar, Miguel A.
Jaime-Lara, Rosario B.
Bravo-Rivera, Hector
Tejeda, Hugo A.
Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders
title Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders
title_full Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders
title_fullStr Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders
title_full_unstemmed Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders
title_short Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders
title_sort neuropeptide system regulation of prefrontal cortex circuitry: implications for neuropsychiatric disorders
topic Neural Circuits
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255232/
https://www.ncbi.nlm.nih.gov/pubmed/35800635
http://dx.doi.org/10.3389/fncir.2022.796443
work_keys_str_mv AT casellosannem neuropeptidesystemregulationofprefrontalcortexcircuitryimplicationsforneuropsychiatricdisorders
AT floresrodolfoj neuropeptidesystemregulationofprefrontalcortexcircuitryimplicationsforneuropsychiatricdisorders
AT yarurhectore neuropeptidesystemregulationofprefrontalcortexcircuitryimplicationsforneuropsychiatricdisorders
AT wanghuikun neuropeptidesystemregulationofprefrontalcortexcircuitryimplicationsforneuropsychiatricdisorders
AT awanyaimonique neuropeptidesystemregulationofprefrontalcortexcircuitryimplicationsforneuropsychiatricdisorders
AT arenivarmiguela neuropeptidesystemregulationofprefrontalcortexcircuitryimplicationsforneuropsychiatricdisorders
AT jaimelararosariob neuropeptidesystemregulationofprefrontalcortexcircuitryimplicationsforneuropsychiatricdisorders
AT bravoriverahector neuropeptidesystemregulationofprefrontalcortexcircuitryimplicationsforneuropsychiatricdisorders
AT tejedahugoa neuropeptidesystemregulationofprefrontalcortexcircuitryimplicationsforneuropsychiatricdisorders