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Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders
Neuropeptides, a diverse class of signaling molecules in the nervous system, modulate various biological effects including membrane excitability, synaptic transmission and synaptogenesis, gene expression, and glial cell architecture and function. To date, most of what is known about neuropeptide act...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255232/ https://www.ncbi.nlm.nih.gov/pubmed/35800635 http://dx.doi.org/10.3389/fncir.2022.796443 |
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author | Casello, Sanne M. Flores, Rodolfo J. Yarur, Hector E. Wang, Huikun Awanyai, Monique Arenivar, Miguel A. Jaime-Lara, Rosario B. Bravo-Rivera, Hector Tejeda, Hugo A. |
author_facet | Casello, Sanne M. Flores, Rodolfo J. Yarur, Hector E. Wang, Huikun Awanyai, Monique Arenivar, Miguel A. Jaime-Lara, Rosario B. Bravo-Rivera, Hector Tejeda, Hugo A. |
author_sort | Casello, Sanne M. |
collection | PubMed |
description | Neuropeptides, a diverse class of signaling molecules in the nervous system, modulate various biological effects including membrane excitability, synaptic transmission and synaptogenesis, gene expression, and glial cell architecture and function. To date, most of what is known about neuropeptide action is limited to subcortical brain structures and tissue outside of the central nervous system. Thus, there is a knowledge gap in our understanding of neuropeptide function within cortical circuits. In this review, we provide a comprehensive overview of various families of neuropeptides and their cognate receptors that are expressed in the prefrontal cortex (PFC). Specifically, we highlight dynorphin, enkephalin, corticotropin-releasing factor, cholecystokinin, somatostatin, neuropeptide Y, and vasoactive intestinal peptide. Further, we review the implication of neuropeptide signaling in prefrontal cortical circuit function and use as potential therapeutic targets. Together, this review summarizes established knowledge and highlights unknowns of neuropeptide modulation of neural function underlying various biological effects while offering insights for future research. An increased emphasis in this area of study is necessary to elucidate basic principles of the diverse signaling molecules used in cortical circuits beyond fast excitatory and inhibitory transmitters as well as consider components of neuropeptide action in the PFC as a potential therapeutic target for neurological disorders. Therefore, this review not only sheds light on the importance of cortical neuropeptide studies, but also provides a comprehensive overview of neuropeptide action in the PFC to serve as a roadmap for future studies in this field. |
format | Online Article Text |
id | pubmed-9255232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92552322022-07-06 Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders Casello, Sanne M. Flores, Rodolfo J. Yarur, Hector E. Wang, Huikun Awanyai, Monique Arenivar, Miguel A. Jaime-Lara, Rosario B. Bravo-Rivera, Hector Tejeda, Hugo A. Front Neural Circuits Neural Circuits Neuropeptides, a diverse class of signaling molecules in the nervous system, modulate various biological effects including membrane excitability, synaptic transmission and synaptogenesis, gene expression, and glial cell architecture and function. To date, most of what is known about neuropeptide action is limited to subcortical brain structures and tissue outside of the central nervous system. Thus, there is a knowledge gap in our understanding of neuropeptide function within cortical circuits. In this review, we provide a comprehensive overview of various families of neuropeptides and their cognate receptors that are expressed in the prefrontal cortex (PFC). Specifically, we highlight dynorphin, enkephalin, corticotropin-releasing factor, cholecystokinin, somatostatin, neuropeptide Y, and vasoactive intestinal peptide. Further, we review the implication of neuropeptide signaling in prefrontal cortical circuit function and use as potential therapeutic targets. Together, this review summarizes established knowledge and highlights unknowns of neuropeptide modulation of neural function underlying various biological effects while offering insights for future research. An increased emphasis in this area of study is necessary to elucidate basic principles of the diverse signaling molecules used in cortical circuits beyond fast excitatory and inhibitory transmitters as well as consider components of neuropeptide action in the PFC as a potential therapeutic target for neurological disorders. Therefore, this review not only sheds light on the importance of cortical neuropeptide studies, but also provides a comprehensive overview of neuropeptide action in the PFC to serve as a roadmap for future studies in this field. Frontiers Media S.A. 2022-06-21 /pmc/articles/PMC9255232/ /pubmed/35800635 http://dx.doi.org/10.3389/fncir.2022.796443 Text en Copyright © 2022 Casello, Flores, Yarur, Wang, Awanyai, Arenivar, Jaime-Lara, Bravo-Rivera and Tejeda. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neural Circuits Casello, Sanne M. Flores, Rodolfo J. Yarur, Hector E. Wang, Huikun Awanyai, Monique Arenivar, Miguel A. Jaime-Lara, Rosario B. Bravo-Rivera, Hector Tejeda, Hugo A. Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders |
title | Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders |
title_full | Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders |
title_fullStr | Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders |
title_full_unstemmed | Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders |
title_short | Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders |
title_sort | neuropeptide system regulation of prefrontal cortex circuitry: implications for neuropsychiatric disorders |
topic | Neural Circuits |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255232/ https://www.ncbi.nlm.nih.gov/pubmed/35800635 http://dx.doi.org/10.3389/fncir.2022.796443 |
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