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Rheological design of thickened alcohol-based hand rubs

The handleability and sensory perception of hand sanitisers by consumers affect the hygiene outcome. Spillage may result in under-dosing and poor sensory properties can lead to under-utilisation. We first propose four principles (low runoff, spreadability, smoothness and non-stickiness) for designin...

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Autores principales: Silva, Andreia F, Wood, Tiffany A, Hodgson, Daniel J M, Royer, John R, Thijssen, Job H J, Lips, Alex, Poon, Wilson C K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255512/
https://www.ncbi.nlm.nih.gov/pubmed/35811745
http://dx.doi.org/10.1007/s00397-022-01347-y
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author Silva, Andreia F
Wood, Tiffany A
Hodgson, Daniel J M
Royer, John R
Thijssen, Job H J
Lips, Alex
Poon, Wilson C K
author_facet Silva, Andreia F
Wood, Tiffany A
Hodgson, Daniel J M
Royer, John R
Thijssen, Job H J
Lips, Alex
Poon, Wilson C K
author_sort Silva, Andreia F
collection PubMed
description The handleability and sensory perception of hand sanitisers by consumers affect the hygiene outcome. Spillage may result in under-dosing and poor sensory properties can lead to under-utilisation. We first propose four principles (low runoff, spreadability, smoothness and non-stickiness) for designing the rheology of thickened alcohol-based hand rubs with acceptable handleability and hand feel. We then evaluate a commercial hand gel and a variety of simplified formulations thickened with microgels (Carbopol 974P, Carbopol Ultrez 20 and Sepimax Zen), or linear polymers (Jaguar HP 120 COS), and evaluate them against these design criteria. All four additives provide acceptable spreadability by shear thinning to [Formula: see text] at [Formula: see text] . Either the finite yield stress conferred by the microgels ([Formula: see text] ) or the increase in low-shear viscosity provided by the linear polymer ([Formula: see text] at [Formula: see text] ) give rise to acceptably low runoff. However, the formulation using the linear polymer shows a filament breakage time of [Formula: see text] in capillary rheology, which may result in stickiness and therefore a less than optimal hand feel.
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spelling pubmed-92555122022-07-06 Rheological design of thickened alcohol-based hand rubs Silva, Andreia F Wood, Tiffany A Hodgson, Daniel J M Royer, John R Thijssen, Job H J Lips, Alex Poon, Wilson C K Rheol Acta Original Contribution The handleability and sensory perception of hand sanitisers by consumers affect the hygiene outcome. Spillage may result in under-dosing and poor sensory properties can lead to under-utilisation. We first propose four principles (low runoff, spreadability, smoothness and non-stickiness) for designing the rheology of thickened alcohol-based hand rubs with acceptable handleability and hand feel. We then evaluate a commercial hand gel and a variety of simplified formulations thickened with microgels (Carbopol 974P, Carbopol Ultrez 20 and Sepimax Zen), or linear polymers (Jaguar HP 120 COS), and evaluate them against these design criteria. All four additives provide acceptable spreadability by shear thinning to [Formula: see text] at [Formula: see text] . Either the finite yield stress conferred by the microgels ([Formula: see text] ) or the increase in low-shear viscosity provided by the linear polymer ([Formula: see text] at [Formula: see text] ) give rise to acceptably low runoff. However, the formulation using the linear polymer shows a filament breakage time of [Formula: see text] in capillary rheology, which may result in stickiness and therefore a less than optimal hand feel. Springer Berlin Heidelberg 2022-07-05 2022 /pmc/articles/PMC9255512/ /pubmed/35811745 http://dx.doi.org/10.1007/s00397-022-01347-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Contribution
Silva, Andreia F
Wood, Tiffany A
Hodgson, Daniel J M
Royer, John R
Thijssen, Job H J
Lips, Alex
Poon, Wilson C K
Rheological design of thickened alcohol-based hand rubs
title Rheological design of thickened alcohol-based hand rubs
title_full Rheological design of thickened alcohol-based hand rubs
title_fullStr Rheological design of thickened alcohol-based hand rubs
title_full_unstemmed Rheological design of thickened alcohol-based hand rubs
title_short Rheological design of thickened alcohol-based hand rubs
title_sort rheological design of thickened alcohol-based hand rubs
topic Original Contribution
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255512/
https://www.ncbi.nlm.nih.gov/pubmed/35811745
http://dx.doi.org/10.1007/s00397-022-01347-y
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