Cargando…

IL-17 and IL-17-producing cells in protection versus pathology

IL-17 cytokine family members have diverse biological functions, promoting protective immunity against many pathogens but also driving inflammatory pathology during infection and autoimmunity. IL-17A and IL-17F are produced by CD4(+) and CD8(+) T cells, γδ T cells, and various innate immune cell pop...

Descripción completa

Detalles Bibliográficos
Autor principal: Mills, Kingston H. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255545/
https://www.ncbi.nlm.nih.gov/pubmed/35790881
http://dx.doi.org/10.1038/s41577-022-00746-9
_version_ 1784740943408136192
author Mills, Kingston H. G.
author_facet Mills, Kingston H. G.
author_sort Mills, Kingston H. G.
collection PubMed
description IL-17 cytokine family members have diverse biological functions, promoting protective immunity against many pathogens but also driving inflammatory pathology during infection and autoimmunity. IL-17A and IL-17F are produced by CD4(+) and CD8(+) T cells, γδ T cells, and various innate immune cell populations in response to IL-1β and IL-23, and they mediate protective immunity against fungi and bacteria by promoting neutrophil recruitment, antimicrobial peptide production and enhanced barrier function. IL-17-driven inflammation is normally controlled by regulatory T cells and the anti-inflammatory cytokines IL-10, TGFβ and IL-35. However, if dysregulated, IL-17 responses can promote immunopathology in the context of infection or autoimmunity. Moreover, IL-17 has been implicated in the pathogenesis of many other disorders with an inflammatory basis, including cardiovascular and neurological diseases. Consequently, the IL-17 pathway is now a key drug target in many autoimmune and chronic inflammatory disorders; therapeutic monoclonal antibodies targeting IL-17A, both IL-17A and IL-17F, the IL-17 receptor, or IL-23 are highly effective in some of these diseases. However, new approaches are needed to specifically regulate IL-17-mediated immunopathology in chronic inflammation and autoimmunity without compromising protective immunity to infection.
format Online
Article
Text
id pubmed-9255545
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-92555452022-07-06 IL-17 and IL-17-producing cells in protection versus pathology Mills, Kingston H. G. Nat Rev Immunol Review Article IL-17 cytokine family members have diverse biological functions, promoting protective immunity against many pathogens but also driving inflammatory pathology during infection and autoimmunity. IL-17A and IL-17F are produced by CD4(+) and CD8(+) T cells, γδ T cells, and various innate immune cell populations in response to IL-1β and IL-23, and they mediate protective immunity against fungi and bacteria by promoting neutrophil recruitment, antimicrobial peptide production and enhanced barrier function. IL-17-driven inflammation is normally controlled by regulatory T cells and the anti-inflammatory cytokines IL-10, TGFβ and IL-35. However, if dysregulated, IL-17 responses can promote immunopathology in the context of infection or autoimmunity. Moreover, IL-17 has been implicated in the pathogenesis of many other disorders with an inflammatory basis, including cardiovascular and neurological diseases. Consequently, the IL-17 pathway is now a key drug target in many autoimmune and chronic inflammatory disorders; therapeutic monoclonal antibodies targeting IL-17A, both IL-17A and IL-17F, the IL-17 receptor, or IL-23 are highly effective in some of these diseases. However, new approaches are needed to specifically regulate IL-17-mediated immunopathology in chronic inflammation and autoimmunity without compromising protective immunity to infection. Nature Publishing Group UK 2022-07-05 2023 /pmc/articles/PMC9255545/ /pubmed/35790881 http://dx.doi.org/10.1038/s41577-022-00746-9 Text en © Springer Nature Limited 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Article
Mills, Kingston H. G.
IL-17 and IL-17-producing cells in protection versus pathology
title IL-17 and IL-17-producing cells in protection versus pathology
title_full IL-17 and IL-17-producing cells in protection versus pathology
title_fullStr IL-17 and IL-17-producing cells in protection versus pathology
title_full_unstemmed IL-17 and IL-17-producing cells in protection versus pathology
title_short IL-17 and IL-17-producing cells in protection versus pathology
title_sort il-17 and il-17-producing cells in protection versus pathology
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255545/
https://www.ncbi.nlm.nih.gov/pubmed/35790881
http://dx.doi.org/10.1038/s41577-022-00746-9
work_keys_str_mv AT millskingstonhg il17andil17producingcellsinprotectionversuspathology