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Cecal Microbial Hydrogen Cycling Potential Is Linked to Feed Efficiency Phenotypes in Chickens
In chickens, early life exposure to environmental microbes has long-lasting impacts on gastrointestinal (GI) microbiome development and host health and growth, via mechanisms that remain uncharacterized. In this study, we demonstrated that administrating a fecal microbiome transplant (FMT) from adul...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255636/ https://www.ncbi.nlm.nih.gov/pubmed/35799838 http://dx.doi.org/10.3389/fvets.2022.904698 |
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author | Ramírez, Gustavo Antonio Keshri, Jitendra Vahrson, Isabella Garber, Arkadiy I. Berrang, Mark E. Cox, Nelson A. González-Cerón, Fernando Aggrey, Samuel E. Oakley, Brian B. |
author_facet | Ramírez, Gustavo Antonio Keshri, Jitendra Vahrson, Isabella Garber, Arkadiy I. Berrang, Mark E. Cox, Nelson A. González-Cerón, Fernando Aggrey, Samuel E. Oakley, Brian B. |
author_sort | Ramírez, Gustavo Antonio |
collection | PubMed |
description | In chickens, early life exposure to environmental microbes has long-lasting impacts on gastrointestinal (GI) microbiome development and host health and growth, via mechanisms that remain uncharacterized. In this study, we demonstrated that administrating a fecal microbiome transplant (FMT) from adults to day-of-hatch chicks results in significantly higher body mass of birds and decreased residual feed intake (RFI), implying enhanced feed efficiency, at 6 weeks of age. To assess the potential mechanisms through which FMT affects adult bird phenotype, we combined 16 S rRNA gene amplification, metagenomic, and comparative genomic approaches to survey the composition and predicted activities of the resident microbiome of various GI tract segments. Early life FMT exposure had a long-lasting significant effect on the microbial community composition and function of the ceca but not on other GI segments. Within the ceca of 6-week-old FMT birds, hydrogenotrophic microbial lineages and genes were most differentially enriched. The results suggest that thermodynamic regulation in the cecum, in this case via hydrogenotrophic methanogenic and sulfur-cycling lineages, potentially serving as hydrogen sinks, may enhance fermentative efficiency and dietary energy harvest capacity. Our study provides a specific mechanism of action through which early-life microbiome transplants modulate market-relevant phenotypes in poultry and, thereby, may represent a significant advance toward microbiome-focused sustainable agriculture. |
format | Online Article Text |
id | pubmed-9255636 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92556362022-07-06 Cecal Microbial Hydrogen Cycling Potential Is Linked to Feed Efficiency Phenotypes in Chickens Ramírez, Gustavo Antonio Keshri, Jitendra Vahrson, Isabella Garber, Arkadiy I. Berrang, Mark E. Cox, Nelson A. González-Cerón, Fernando Aggrey, Samuel E. Oakley, Brian B. Front Vet Sci Veterinary Science In chickens, early life exposure to environmental microbes has long-lasting impacts on gastrointestinal (GI) microbiome development and host health and growth, via mechanisms that remain uncharacterized. In this study, we demonstrated that administrating a fecal microbiome transplant (FMT) from adults to day-of-hatch chicks results in significantly higher body mass of birds and decreased residual feed intake (RFI), implying enhanced feed efficiency, at 6 weeks of age. To assess the potential mechanisms through which FMT affects adult bird phenotype, we combined 16 S rRNA gene amplification, metagenomic, and comparative genomic approaches to survey the composition and predicted activities of the resident microbiome of various GI tract segments. Early life FMT exposure had a long-lasting significant effect on the microbial community composition and function of the ceca but not on other GI segments. Within the ceca of 6-week-old FMT birds, hydrogenotrophic microbial lineages and genes were most differentially enriched. The results suggest that thermodynamic regulation in the cecum, in this case via hydrogenotrophic methanogenic and sulfur-cycling lineages, potentially serving as hydrogen sinks, may enhance fermentative efficiency and dietary energy harvest capacity. Our study provides a specific mechanism of action through which early-life microbiome transplants modulate market-relevant phenotypes in poultry and, thereby, may represent a significant advance toward microbiome-focused sustainable agriculture. Frontiers Media S.A. 2022-06-21 /pmc/articles/PMC9255636/ /pubmed/35799838 http://dx.doi.org/10.3389/fvets.2022.904698 Text en Copyright © 2022 Ramírez, Keshri, Vahrson, Garber, Berrang, Cox, González-Cerón, Aggrey and Oakley. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Veterinary Science Ramírez, Gustavo Antonio Keshri, Jitendra Vahrson, Isabella Garber, Arkadiy I. Berrang, Mark E. Cox, Nelson A. González-Cerón, Fernando Aggrey, Samuel E. Oakley, Brian B. Cecal Microbial Hydrogen Cycling Potential Is Linked to Feed Efficiency Phenotypes in Chickens |
title | Cecal Microbial Hydrogen Cycling Potential Is Linked to Feed Efficiency Phenotypes in Chickens |
title_full | Cecal Microbial Hydrogen Cycling Potential Is Linked to Feed Efficiency Phenotypes in Chickens |
title_fullStr | Cecal Microbial Hydrogen Cycling Potential Is Linked to Feed Efficiency Phenotypes in Chickens |
title_full_unstemmed | Cecal Microbial Hydrogen Cycling Potential Is Linked to Feed Efficiency Phenotypes in Chickens |
title_short | Cecal Microbial Hydrogen Cycling Potential Is Linked to Feed Efficiency Phenotypes in Chickens |
title_sort | cecal microbial hydrogen cycling potential is linked to feed efficiency phenotypes in chickens |
topic | Veterinary Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255636/ https://www.ncbi.nlm.nih.gov/pubmed/35799838 http://dx.doi.org/10.3389/fvets.2022.904698 |
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