Cargando…

Albumin uptake and processing by the proximal tubule: physiological, pathological, and therapeutic implications

For nearly 50 years the proximal tubule (PT) has been known to reabsorb, process, and either catabolize or transcytose albumin from the glomerular filtrate. Innovative techniques and approaches have provided insights into these processes. Several genetic diseases, nonselective PT cell defects, chron...

Descripción completa

Detalles Bibliográficos
Autores principales:	Molitoris, Bruce A., Sandoval, Ruben M., Yadav, Shiv Pratap S., Wagner, Mark C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Physiological Society 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255719/ https://www.ncbi.nlm.nih.gov/pubmed/35378997 http://dx.doi.org/10.1152/physrev.00014.2021

Ejemplares similares

Lrpap1 (RAP) Inhibits Proximal Tubule Clathrin Mediated and Clathrin Independent Endocytosis, Ameliorating Renal Aminoglycoside Nephrotoxicity
por: Wagner, Mark C., et al.
Publicado: (2023)

Intravital Multiphoton Microscopy as a Tool for Studying Renal Physiology, Pathophysiology and Therapeutics
por: Molitoris, Bruce A., et al.
Publicado: (2022)

Glycosylation of a key cubilin Asn residue results in reduced binding to albumin
por: Yadav, Shiv Pratap Singh, et al.
Publicado: (2022)

Albumin Uptake in OK Cells Exposed to Rotenone: A Model for Studying the Effects of Mitochondrial Dysfunction on Endocytosis in the Proximal Tubule?
por: Hall, A.M., et al.
Publicado: (2010)

Akt Links Insulin Signaling to Albumin Endocytosis in Proximal Tubule Epithelial Cells
por: Coffey, Sam, et al.
Publicado: (2015)

Albumin Expands Albumin Reabsorption Capacity in Proximal Tubule Epithelial Cells through a Positive Feedback Loop between AKT and Megalin
por: Silva-Aguiar, Rodrigo P., et al.
Publicado: (2022)

Light Chain Restriction in Proximal Tubules—Implications for Light Chain Proximal Tubulopathy
por: Büttner-Herold, Maike, et al.
Publicado: (2022)

Changes in the Expression of Renal Brush Border Membrane N-Glycome in Model Rats with Chronic Kidney Diseases
por: Yu, Aiying, et al.
Publicado: (2021)

Insulin uptake across the luminal membrane of the rat proximal tubule in vivo and in vitro
por: Kolman, Pavel, et al.
Publicado: (2009)

5-Lypoxygenase Products Are Involved in Renal Tubulointerstitial Injury Induced by Albumin Overload in Proximal Tubules in Mice
por: Landgraf, Sharon Schilling, et al.
Publicado: (2014)

The caspase 3 sensor Phiphilux G2D2 is activated non-specifically in S1 renal proximal tubules
por: Hato, Takashi, et al.
Publicado: (2015)

In Vitro Evaluation of the Effects of Cadmium on Endocytic Uptakes of Proteins into Cultured Proximal Tubule Epithelial Cells
por: Fujishiro, Hitomi, et al.
Publicado: (2020)

Altered O-glycomes of Renal Brush-Border Membrane in Model Rats with Chronic Kidney Diseases
por: Yu, Aiying, et al.
Publicado: (2021)

The Proximal Tubule Cell in Experimental Hydronephrosis
por: Novikoff, Alex B.
Publicado: (1959)

Rheogenic transport in the renal proximal tubule
Publicado: (1983)

Is the proximal tubule the focus of tubulointerstitial fibrosis?
por: Peng, Zhi, et al.
Publicado: (2023)

VPS34 functions in the proximal tubule
por: Allison, Susan J.
Publicado: (2023)

Cadmium Impairs Albumin Reabsorption by Down-regulating Megalin and ClC5 Channels in Renal Proximal Tubule Cells
por: Gena, Patrizia, et al.
Publicado: (2010)

SARS-CoV-2 spike protein inhibits megalin-mediated albumin endocytosis in proximal tubule epithelial cells
por: Silva-Aguiar, Rodrigo P., et al.
Publicado: (2022)

3D proximal tubule-on-chip model derived from kidney organoids with improved drug uptake
por: Aceves, Jeffrey O., et al.
Publicado: (2022)

Epicardial Fat: Physiological, Pathological, and Therapeutic Implications
por: Salazar, Juan, et al.
Publicado: (2016)

Insertion of an axial electrode into renal proximal tubule.
por: Spring, K. R.
Publicado: (1972)

Conductive properties of the proximal tubule in Necturus kidney
Publicado: (1980)

Analysis of standing droplets in rat proximal tubules
Publicado: (1982)

Kinetics of Na(+) transport in necturus proximal tubule
por: Spring, KR, et al.
Publicado: (1977)

Isosmotic volume reabsorption in rat proximal tubule
Publicado: (1980)

Iron Is Filtered by the Kidney and Is Reabsorbed by the Proximal Tubule
por: Wareing, Mark, et al.
Publicado: (2021)

Proximal Tubule Dysfunction Secondary to Salicylate Intoxication
por: Taylor, Zachary C., et al.
Publicado: (2022)

The Proximal Tubule Toxicity of Immunoglobulin Light Chains
por: Sirac, Christophe, et al.
Publicado: (2021)

Renal proximal tubule cells: power and finesse
por: Fuchs, Michaela A.A., et al.
Publicado: (2023)

The Physiology and Pathophysiology of T-Tubules in the Heart
por: Setterberg, Ingunn E., et al.
Publicado: (2021)

PBRM1 loss in kidney cancer unbalances the proximal tubule master transcription factor hub to repress proximal tubule differentiation
por: Gu, Xiaorong, et al.
Publicado: (2021)

Intravital multi-photon microscopy reveals several levels of heterogeneity in endocytic uptake by mouse renal proximal tubules
por: Caplanusi, A, et al.
Publicado: (2008)

3D Proximal Tubule Tissues Recapitulate Key Aspects of Renal Physiology to Enable Nephrotoxicity Testing
por: King, Shelby M., et al.
Publicado: (2017)

An Adaptable Physiological Model of Endocytic Megalin Trafficking in Opossum Kidney Cells and Mouse Kidney Proximal Tubule
por: Shipman, Katherine E, et al.
Publicado: (2022)

Transformation of human kidney proximal tubule cells by ras-containing retroviruses. Implications for tumor progression
Publicado: (1989)

Luseogliflozin, a SGLT2 Inhibitor, Does Not Affect Glucose Uptake Kinetics in Renal Proximal Tubules of Live Mice
por: Zhang, Anqi, et al.
Publicado: (2021)

POTASSIUM ACCUMULATION IN THE PROXIMAL CONVOLUTED TUBULES OF THE FROG'S KIDNEY
por: Conway, E. J., et al.
Publicado: (1946)

Osmotic Volume Flow in the Proximal Tubule of Necturus Kidney
por: Bentzel, Carl J., et al.
Publicado: (1968)

Electro-osmosis and the reabsorption of fluid in renal proximal tubules
Publicado: (1985)

Cannot write session to /tmp/vufind_sessions/sess_3gd98cjgpp6fs7pteijms66ahm