Deletion C-terminal thioesterase abolishes melanin biosynthesis, affects metabolism and reduces the pathogenesis of Fonsecaea monophora

Dematiaceous Fonsecaea monophora is one of the major pathogens of chromoblastomycosis. It has been well established that melanization is catalyzed by the type I polyketide synthase (PKS) in F. monophora. Multidomain protein Type I PKS is encoded by six genes, in which the last enzyme thioesterase (T...

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Detalles Bibliográficos
Autores principales: Li, Minying, Huang, Huan, Liu, Jun, Zhang, Xiaohui, Li, Qian, Li, Dongmei, Luo, Mingfen, Wang, Xiaoyue, Zeng, Weiying, Sun, Jiufeng, Liu, Hongfang, Xi, Liyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255740/
https://www.ncbi.nlm.nih.gov/pubmed/35696422
http://dx.doi.org/10.1371/journal.pntd.0010485

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