A single amino acid residue in bank vole prion protein drives permissiveness to Nor98/atypical scrapie and the emergence of multiple strain variants

Prions are infectious agents that replicate through the autocatalytic misfolding of the cellular prion protein (PrP(C)) into infectious aggregates (PrP(Sc)) causing fatal neurodegenerative diseases in humans and animals. Prions exist as strains, which are encoded by conformational variants of PrP(Sc...

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Detalles Bibliográficos
Autores principales: Pirisinu, Laura, Di Bari, Michele Angelo, D’Agostino, Claudia, Vanni, Ilaria, Riccardi, Geraldina, Marcon, Stefano, Vaccari, Gabriele, Chiappini, Barbara, Benestad, Sylvie L., Agrimi, Umberto, Nonno, Romolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255773/
https://www.ncbi.nlm.nih.gov/pubmed/35731839
http://dx.doi.org/10.1371/journal.ppat.1010646

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