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Role of hypoxia inducible factor 1α in cobalt nanoparticle induced cytotoxicity of human THP-1 macrophages

Cobalt is one of the main components of metal hip prostheses and cobalt nanoparticles (CoNPs) produced from wear cause inflammation, bone lyses and cytotoxicity at high concentrations. Cobalt ions mimic hypoxia in the presence of normal oxygen levels, and activate hypoxic signalling by stabilising h...

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Detalles Bibliográficos
Autores principales:	Francis, Wendy Rachel, Liu, Zhao, Owens, Sian E, Wang, Xiao, Xue, Huaming, Lord, Alex, Kanamarlapudi, Venkateswarlu, Xia, Zhidao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Chinese Medical Multimedia Press Co., Ltd 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255782/ https://www.ncbi.nlm.nih.gov/pubmed/35836963 http://dx.doi.org/10.12336/biomatertransl.2021.02.004

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