The Critical Role of Ferroptosis in Hepatocellular Carcinoma

Liver cancer is the sixth most frequently diagnosed cancer and the third dominant cause of cancer death worldwide. Ferroptosis is characterized as an iron-dependent form of regulated cell death, with accumulation of lipid peroxides to lethal amounts. Evidences have showed that ferroptosis is closely...

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Autores principales: Pan, Fan, Lin, Xinrong, Hao, Liping, Wang, Ting, Song, Haizhu, Wang, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255949/
https://www.ncbi.nlm.nih.gov/pubmed/35800895
http://dx.doi.org/10.3389/fcell.2022.882571
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author Pan, Fan
Lin, Xinrong
Hao, Liping
Wang, Ting
Song, Haizhu
Wang, Rui
author_facet Pan, Fan
Lin, Xinrong
Hao, Liping
Wang, Ting
Song, Haizhu
Wang, Rui
author_sort Pan, Fan
collection PubMed
description Liver cancer is the sixth most frequently diagnosed cancer and the third dominant cause of cancer death worldwide. Ferroptosis is characterized as an iron-dependent form of regulated cell death, with accumulation of lipid peroxides to lethal amounts. Evidences have showed that ferroptosis is closely associated with HCC, but the mechanisms are still poorly understood. In this review, we mainly summarize the roles of several typical molecules as well as radiotherapy in regulating the ferroptosis process in HCC. Chances are that this review may help address specific issues in the treatment of HCC.
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spelling pubmed-92559492022-07-06 The Critical Role of Ferroptosis in Hepatocellular Carcinoma Pan, Fan Lin, Xinrong Hao, Liping Wang, Ting Song, Haizhu Wang, Rui Front Cell Dev Biol Cell and Developmental Biology Liver cancer is the sixth most frequently diagnosed cancer and the third dominant cause of cancer death worldwide. Ferroptosis is characterized as an iron-dependent form of regulated cell death, with accumulation of lipid peroxides to lethal amounts. Evidences have showed that ferroptosis is closely associated with HCC, but the mechanisms are still poorly understood. In this review, we mainly summarize the roles of several typical molecules as well as radiotherapy in regulating the ferroptosis process in HCC. Chances are that this review may help address specific issues in the treatment of HCC. Frontiers Media S.A. 2022-06-21 /pmc/articles/PMC9255949/ /pubmed/35800895 http://dx.doi.org/10.3389/fcell.2022.882571 Text en Copyright © 2022 Pan, Lin, Hao, Wang, Song and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Pan, Fan
Lin, Xinrong
Hao, Liping
Wang, Ting
Song, Haizhu
Wang, Rui
The Critical Role of Ferroptosis in Hepatocellular Carcinoma
title The Critical Role of Ferroptosis in Hepatocellular Carcinoma
title_full The Critical Role of Ferroptosis in Hepatocellular Carcinoma
title_fullStr The Critical Role of Ferroptosis in Hepatocellular Carcinoma
title_full_unstemmed The Critical Role of Ferroptosis in Hepatocellular Carcinoma
title_short The Critical Role of Ferroptosis in Hepatocellular Carcinoma
title_sort critical role of ferroptosis in hepatocellular carcinoma
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255949/
https://www.ncbi.nlm.nih.gov/pubmed/35800895
http://dx.doi.org/10.3389/fcell.2022.882571
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